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Titolo:
THE SEARCH FOR HUMAN OBESITY GENES
Autore:
COMUZZIE AG; ALLISON DB;
Indirizzi:
RETINA FDN SW,DEPT GENET,POB 760549 SAN ANTONIO TX 78245 COLUMBIA UNIV,COLL PHYS & SURG,ST LUKES ROOSEVELT HOSP,OBES RES CTR NEW YORK NY 10025
Titolo Testata:
Science
fascicolo: 5368, volume: 280, anno: 1998,
pagine: 1374 - 1377
SICI:
0036-8075(1998)280:5368<1374:TSFHOG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; BODY-MASS INDEX; DISCORDANT SIB PAIRS; LINKAGE ANALYSIS; MAJOR GENE; ENVIRONMENTAL CORRELATIONS; RECESSIVE INHERITANCE; EXTREME OVERWEIGHT; PIMA-INDIANS; FAT MASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Comuzzie e D.B. Allison, "THE SEARCH FOR HUMAN OBESITY GENES", Science, 280(5368), 1998, pp. 1374-1377

Abstract

Understanding of the genetic influences on obesity has increased at atremendous rate in recent years. By some estimates, 40 to 70 percent of the variation in obesity-related phenotypes in humans is heritable. Although several single-gene mutations have been shown to cause obesity in animal models, the situation in humans is considerably more complex. The most common forms of human obesity arise from the interactions of multiple genes, environmental factors, and behavior, and this complex etiology makes the search for obesity genes especially challenging. This article discusses the strategies currently being used to search for human obesity genes and recent promising results from these efforts.

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Documento generato il 29/03/20 alle ore 01:54:13