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Titolo:
HELICOBACTER-PYLORI INFECTION ACCELERATES GENE-EXPRESSION OF GLICENTIN IN THE GASTRIC-MUCOSA - ITS ASSOCIATION WITH INTESTINAL METAPLASIA OF THE STOMACH
Autore:
ISHIHARA S; FUKUDA R; MORIYAMA N; ISHIMURA N; KAJI T; KUSHIYAMA Y; AMANO K; HIRAKAWA K; AMANO Y; ADACHI K; ASHIZAWA N; FUKUMOTO S;
Indirizzi:
SHIMANE MED UNIV,DEPT INTERNAL MED 2,89-1 ENYA CHO IZUMO SHIMANE 693 JAPAN SHIMANE MED UNIV,DEPT INTERNAL MED 2 IZUMO SHIMANE 693 JAPAN
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 5, volume: 32, anno: 1997,
pagine: 460 - 464
SICI:
0036-5521(1997)32:5<460:HIAGOG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOCRINE-CELLS; CARCINOMA; PROGLUCAGON;
Keywords:
GLICENTIN; HELICOBACTER PYLORI; INTESTINAL METAPLASIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S. Ishihara et al., "HELICOBACTER-PYLORI INFECTION ACCELERATES GENE-EXPRESSION OF GLICENTIN IN THE GASTRIC-MUCOSA - ITS ASSOCIATION WITH INTESTINAL METAPLASIA OF THE STOMACH", Scandinavian journal of gastroenterology, 32(5), 1997, pp. 460-464

Abstract

Background: Glicentin is an intestinal polypeptide hormone which seems to promote intestinal metaplasia (IM) in the gastric mucosa. The aimof this study was to clarify whether Helicobacter pylori infection accelerates glicentin gene expression. Method: Glicentin mRNA was investigated by reverse-transcription polymerase chain reaction using gastric biopsies from 47 patients examined endoscopically and denying IM. Results: IM was observed in 18 (38.3%) cases histologically, but not in the other 29 (62.7%). Glicentin mRNA was significantly correlated withhistological IM (P < 0.01) and was positively correlated with H. pylori infection (P < 0.05). Conclusion: Our results indicate that H. pylori infection is associated with the induction of glicentin in the gastric mucosa, thus supporting the hypothesis that H. pylori infection accelerates IM of the stomach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:08:19