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Titolo:
EFFECTS OF DIASPIRIN CROSS-LINKED HEMOGLOBIN ON POSTTRAUMATIC CEREBRAL PERFUSION-PRESSURE AND BLOOD-FLOW IN A RODENT MODEL OF DIFFUSE BRAININJURY
Autore:
PIPER IR; GARRIOCH MA; SOUTER MJ; ANDREWS PJD; THOMSON D;
Indirizzi:
SO GEN HOSP,INST NEUROL SCI,DEPT CLIN PHYS,1345 GOVAN RD GLASGOW G51 4TF LANARK SCOTLAND SO GEN HOSP,DEPT ANAESTHESIA GLASGOW G51 4TF LANARK SCOTLAND WESTERN GEN HOSP,DEPT CLIN NEUROSCI EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 5, volume: 80, anno: 1998,
pagine: 639 - 643
SICI:
0007-0912(1998)80:5<639:EODCHO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; HEMOGLOBIN; RATS; HEAD; ISCHEMIA;
Keywords:
BLOOD, REPLACEMENT; BRAIN, BLOOD FLOW; BRAIN, INJURY; BRAIN, INTRACRANIAL PRESSURE; RAT; MODEL, RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
I.R. Piper et al., "EFFECTS OF DIASPIRIN CROSS-LINKED HEMOGLOBIN ON POSTTRAUMATIC CEREBRAL PERFUSION-PRESSURE AND BLOOD-FLOW IN A RODENT MODEL OF DIFFUSE BRAININJURY", British Journal of Anaesthesia, 80(5), 1998, pp. 639-643

Abstract

Diaspirin cross-linked haemoglobin (DCLHb) is a new oxygen carrying blood substitute with vasoactive properties. Vasoactive properties may be mediated via high affinity binding of nitric oxide by the haem moiety. Using a rodent model of head injury combined with ischaemia, we studied the effects of DCLHb on cerebral blood flow (CBF) and intracranial pressure (ICP). Twenty anaesthetized rats were allocated randomly to receive treatment with DCLHb 400 mg kg(-1) i.v. or placebo (oncotically matched plasma protein substitute 4.5% i.v.). To produce diffuselyincreased ICP, after a severe weight drop injury, all animals underwent a 30-min period of bilateral carotid ligation combined with a period of induced hypotension. After reperfusion, DCLHb or placebo was infused and the animals instrumented for measurement of intraventricular ICP and CBF in the region of the sensorimotor cortex using the hydrogenclearance technique. Mean arterial pressure (MAP), ICP, cerebral perfusion pressure (CPP) (CPP=MAP-ICP) and CBF were measured 4 h after injury in all animals. DCLHb significantly reduced ICP from mean 13 (SEM 2) to 3 (1) mm Hg (P<0.001), increased CPP from 52 (8) to 95 (6) mm Hg(P<0.001) and increased CBF from 21 (2) to 29 (2) ml 100 g(-1) min(-1) (P=0.032). We conclude that DCLHb improved CPP without a reduction in CBF in a rodent model of post-traumatic brain swelling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 08:04:22