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Titolo:
FUNCTIONAL AMPA KAINATE RECEPTORS IN HUMAN EMBRYONIC AND FETAL CENTRAL-NERVOUS-SYSTEM/
Autore:
BARDOUL M; LEVALLOIS C; KONIG N;
Indirizzi:
UNIV MONTPELLIER 2,INSERM,U336,USTL CASE 106,PL E BATAILLON F-34095 MONTPELLIER FRANCE UNIV MONTPELLIER 2,INSERM,U336 F-34095 MONTPELLIER FRANCE UNIV MONTPELLIER 2,EPHE NEUROBIOL CELLULAIRE QUANTITAT F-34095 MONTPELLIER FRANCE
Titolo Testata:
Journal of chemical neuroanatomy
fascicolo: 2, volume: 14, anno: 1998,
pagine: 79 - 85
SICI:
0891-0618(1998)14:2<79:FAKRIH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE RECEPTORS; KAINATE RECEPTORS; CORTICAL-NEURONS; AMPA RECEPTORS; HUMAN BRAIN; RAT-BRAIN; CYCLOTHIAZIDE; CELLS; EXPRESSION; SENSITIVITY;
Keywords:
GLUTAMATE; DEVELOPMENT; CALCIUM; COBALT; RECEPTOR DESENSITIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Bardoul et al., "FUNCTIONAL AMPA KAINATE RECEPTORS IN HUMAN EMBRYONIC AND FETAL CENTRAL-NERVOUS-SYSTEM/", Journal of chemical neuroanatomy, 14(2), 1998, pp. 79-85

Abstract

Here, functional AMPA/kainate receptors in human embryonic (5.5-7.5 gestational weeks) and foetal (8-10 gestational weeks) central nervous system tissue, shown by the cobalt labeling method, are reported. Specific agonist-induced cobalt incorporation was detected in brainstem and spinal cord cells, even in the youngest embryo studied. T-AMPA or kainate, but also vegetal toxins such as L-BOAA or acromelate, induced accumulation of cobalt. In contrast, no labeling was observed after exposure to KCl or NMDA. Cobalt labeled cells were particularly prominentin motor regions of brainstem and spinal cord. Go-application of the diuretic agent cyclothiazide, a desensitization blocker at AMPA receptors, dramatically increased the number of stained cells, which was particularly obvious in sensory regions, suggesting different receptor properties in motor versus sensory regions. This is the first study providing evidence for functional AMPA/kainate receptors, permeable to divalent cations, in brainstem and spinal cord at an early stage of humancentral nervous system development. Since many developmental processes are influenced by the modulation of cytosolic calcium, exposure at critical stages of embryogenesis to food or drug substances modifying the activity of AMPA/kainate receptors may alter brain development. (C)1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 23:20:25