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Titolo:
THIOURONINM-THYMINE CONJUGATE AS A NEW CARRIER FOR SELECTIVE TRANSPORT OF 5'-AMP
Autore:
YEO WS; HONG JI;
Indirizzi:
SEOUL NATL UNIV,DEPT CHEM SEOUL 151742 SOUTH KOREA
Titolo Testata:
Tetrahedron letters
fascicolo: 22, volume: 39, anno: 1998,
pagine: 3769 - 3772
SICI:
0040-4039(1998)39:22<3769:TCAANC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR RECOGNITION; ANION-BINDING; NUCLEOTIDE MONOPHOSPHATES; NEUTRAL RECEPTORS; PHOSPHATE; COMPLEMENTARITY; SITE; UREA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
W.S. Yeo e J.I. Hong, "THIOURONINM-THYMINE CONJUGATE AS A NEW CARRIER FOR SELECTIVE TRANSPORT OF 5'-AMP", Tetrahedron letters, 39(22), 1998, pp. 3769-3772

Abstract

Extraction and transport behaviors of the new 5'-AMP receptors which have thiouronium group and which have both thiouronium and thymine group were investigated. As expected, the sequence of transport rate was 1 > 3 similar to 2 > 4. 1 showed the best transport ability, since it has both concave bis(thiouronium) binding site which can chelate phospate anion and covalently linked bis(thymine) moiety which can interactwith adenine in 5'-AMP by hydrogen bonding involving both Watson-Crick and Hoogsteen recognition patterns. The less transport ability of 2 and 4 was assumed to be the result of disadvantage in complexation process entropically and enthalpically. The control experiment clearly showed that selective base-pairing contributed to increased transport. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:19:19