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Titolo:
THE VASOACTIVE PEPTIDE MAXADILAN FROM SAND FLY SALIVA INHIBITS TNF-ALPHA AND INDUCES IL-6 BY MOUSE MACROPHAGES THROUGH INTERACTION WITH THEPITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) RECEPTOR
Autore:
SOARES MBP; TITUS RG; SHOEMAKER CB; DAVID JR; BOZZA M;
Indirizzi:
FDN OSWALDO CRUZ,AV BRAZIL 4365 BR-21045900 RIO JANEIRO BRAZIL HARVARD UNIV,SCH PUBL HLTH,DEPT TROP PUBL HLTH BOSTON MA 02115 COLORADO STATE UNIV,COLL VET MED & BIOMED SCI,DEPT PATHOL FT COLLINS CO 80523
Titolo Testata:
The Journal of immunology
fascicolo: 4, volume: 160, anno: 1998,
pagine: 1811 - 1816
SICI:
0022-1767(1998)160:4<1811:TVPMFS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE PERITONEAL-MACROPHAGES; NECROSIS FACTOR PRODUCTION; CELLULAR IMMUNE-RESPONSES; LUTZOMYIA-LONGIPALPIS; LEISHMANIA-MAJOR; GENE-EXPRESSION; HUMAN-MONOCYTES; VASODILATORY PEPTIDE; CYTOKINE PRODUCTION; INTESTINAL-PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
M.B.P. Soares et al., "THE VASOACTIVE PEPTIDE MAXADILAN FROM SAND FLY SALIVA INHIBITS TNF-ALPHA AND INDUCES IL-6 BY MOUSE MACROPHAGES THROUGH INTERACTION WITH THEPITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) RECEPTOR", The Journal of immunology, 160(4), 1998, pp. 1811-1816

Abstract

Maxadilan is a vasodilatory peptide encoded by a gene cloned from Lutzomyia longipalpis salivary glands. In this study rye investigated theeffects of maxadilan on macrophage functions. Maxadilan treatment of LPS-stimulated BALB/c macrophages inhibited TNF-alpha release but increased IL-6, Further, it also induced IL-6 release in a dose-dependent manner from unstimulated macrophages, Maxadilan increased production of PGE(2), and the inhibition of TNF-alpha was completely abrogated by indomethacin, Others have recently shown that maxadilan is a selectiveagonist of the pituitary adenylate cyclase-activating polypeptide (PACAP) type I receptor, Treatment with the receptor antagonist PACAP 6-38 blocked maxadilan activities on macrophages, The natural endogenous ligand, PACAP 38, had the same effects as maxadilan on TNF-alpha and IL-6 production. Finally, in a dose- and time-dependent fashion, maxadilan induced the intracellular accumulation of cAMP in macrophages. Taken together, the results presented here indicate a modulatory effect of ligands of PACAP type I receptor on cytokine production by macrophages and suggest that activation of this receptor, with the subsequent elevation of intracellular cAMP in macrophages, could participate in a negative-feedback mechanism that controls certain inflammatory responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:18:08