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Titolo:
THE PREVALENCE OF AND RISK-FACTORS FOR ATOPY IN EARLY-CHILDHOOD - A WHOLE POPULATION BIRTH COHORT STUDY
Autore:
TARIQ SM; MATTHEWS SM; HAKIM EA; STEVENS M; ARSHAD SH; HIDE DW;
Indirizzi:
ST MARYS HOSP,DAVID HIDE ASTHMA & ALLERGY RES CTR NEWPORT PO30 5TG WIGHT ENGLAND ST MARYS HOSP,DAVID HIDE ASTHMA & ALLERGY RES CTR NEWPORT PO30 5TG WIGHT ENGLAND
Titolo Testata:
Journal of allergy and clinical immunology
fascicolo: 5, volume: 101, anno: 1998,
pagine: 587 - 593
SICI:
0091-6749(1998)101:5<587:TPOARF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORD SERUM IGE; BRONCHIAL RESPONSIVENESS; ENVIRONMENTAL-FACTORS; ALLERGIC DISORDERS; PARENTAL SMOKING; ASTHMA; SENSITIZATION; CHILDREN; AGE; INFANCY;
Keywords:
ATOPY; FAMILY HISTORY; CORD IGE; ASTHMA; ECZEMA; ALLERGIC RHINITIS; BIRTH COHORT; SKIN PRICK TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Tariq et al., "THE PREVALENCE OF AND RISK-FACTORS FOR ATOPY IN EARLY-CHILDHOOD - A WHOLE POPULATION BIRTH COHORT STUDY", Journal of allergy and clinical immunology, 101(5), 1998, pp. 587-593

Abstract

Objectives: A birth cohort was followed-up to age 4 years to record the development of allergic disorders and to study the influence of genetic and environmental factors. Methods: Information on family historyand environmental factors was obtained at birth, and serum cord IgE was measured. At age 4 years, 1218 children were reviewed. Results: By age 4 years, 27% of the children had symptoms of allergic disease. Period prevalence of asthma increased from 8.7% in infancy to 14.9% at 4 years; Family history of atopy was the single most important risk factor for atopy in children. Sibling atopy was a stronger predictor of clinical disease than maternal dr paternal atopy, whereas paternal atopy, male sex, and high cord IgE were significant for the development of allergen sensitization. Children of asthmatic mothers were three timesmore likely to have asthma (odds ratio [OR]: 3.0, 95% confidence interval [CI]: 1.6-5.8) and rhinitis (OR: 2.9, CI: 1.1-7.4). Formula feeding before 3 months of age predisposed to asthma at age 4 years (OR: 1.8, CI: 1.2-2.6). The effect of maternal smoking on childhood wheeze seen at 1 and 2 years was lost by age 4, except for a subgroup with negative skin test responses (nonatopic asthma). Less than half (46%) of the infantile wheezers were still wheezing at 4 years of age. Conclusion: Family history of atopy remains the most important risk factor for atopy in children, but other markers can be identified with a potential for Intervention at an early age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:02:01