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Titolo:
EFFECTS OF DESMETHYLCLOZAPINE ON FOS PROTEIN EXPRESSION IN THE FOREBRAIN - IN-VIVO BIOLOGICAL-ACTIVITY OF THE CLOZAPINE METABOLITE
Autore:
YOUNG CD; MELTZER HY; DEUTCH AY;
Indirizzi:
HOSP PSYCHIAT,SUITE 313,1601 23RD AVE S NASHVILLE TN 37212 VANDERBILT UNIV,SCH MED,DEPT PSYCHIAT NASHVILLE TN 37212 VANDERBILT UNIV,SCH MED,DEPT PHARMACOL NASHVILLE TN 37212
Titolo Testata:
Neuropsychopharmacology
fascicolo: 1, volume: 19, anno: 1998,
pagine: 99 - 103
SICI:
0893-133X(1998)19:1<99:EODOFP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; EARLY GENE-EXPRESSION; C-FOS; INDUCED AGRANULOCYTOSIS; SCHIZOPHRENIC-PATIENTS; RECEPTOR ANTAGONISTS; N-DESMETHYLCLOZAPINE; NUCLEUS-ACCUMBENS; PLASMA CLOZAPINE; HALOPERIDOL;
Keywords:
ANTIPSYCHOTIC DRUGS; IMMEDIATE-EARLY GENE; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; SCHIZOPHRENIA; STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Young et al., "EFFECTS OF DESMETHYLCLOZAPINE ON FOS PROTEIN EXPRESSION IN THE FOREBRAIN - IN-VIVO BIOLOGICAL-ACTIVITY OF THE CLOZAPINE METABOLITE", Neuropsychopharmacology, 19(1), 1998, pp. 99-103

Abstract

Several products of the hepatic metabolism of clozapine are found in high concentrations in the plasma of schizophrenic patients treated with this atypical antipsychotic drug. One of these metabolites, N-desmethylclozapine, has substantially different affinities for dopamine andserotonin metabolites than does the parent compound. However, it is not known if this metabolite is active in vivo. We examined the effect of acute administration of desmethylclozapine to rats on forebrain Fosprotein expression. Clozapine induces expression of this immediate-early gene in a distinct regional pattern in the brain. Desmethylclozapine significantly increased Fos protein expression in the medial prefrontal cortex and nucleus accumbens, but not in the dorsolateral striatum, thus mirroring the effects of the parent compound. These data indicate that the desmethyl metabolite of clozapine has in vivo biological activity. (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:12:07