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Titolo:
PLASMA NEUROPEPTIDE-Y (NPY) INCREASES IN HUMANS IN RESPONSE TO THE ALPHA(2) ANTAGONIST YOHIMBINE
Autore:
RASMUSSON AM; SOUTHWICK SM; HAUGER RL; CHARNEY DS;
Indirizzi:
VET ADM MED CTR,PSYCHIAT SERV 116A,NATL CTR PTSD,950 CAMPBELL AVE W HAVEN CT 06516 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 00000 UNIV CALIF SAN DIEGO,SCH MED LA JOLLA CA 92093
Titolo Testata:
Neuropsychopharmacology
fascicolo: 1, volume: 19, anno: 1998,
pagine: 95 - 98
SICI:
0893-133X(1998)19:1<95:PN(IIH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANIC DISORDER PATIENTS; NORADRENERGIC FUNCTION; GUINEA-PIG; ANXIETY; NORADRENALINE; INVOLVEMENT; MODULATION; RECEPTORS; RELEASE; NEURONS;
Keywords:
YOHIMBINE; NEUROPEPTIDE Y (NPY); HUMAN; NORADRENERGIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Rasmusson et al., "PLASMA NEUROPEPTIDE-Y (NPY) INCREASES IN HUMANS IN RESPONSE TO THE ALPHA(2) ANTAGONIST YOHIMBINE", Neuropsychopharmacology, 19(1), 1998, pp. 95-98

Abstract

Previous studies have shown that the intravenous administration of yohimbine, an alpha(2) antagonist, increases norepinephrine turnover andhas related anxiogenic effects in humans. We herein report that yohimbine also increases plasma neuropeptide Y (NPY) in healthy human subjects. This finding is consistent with previous reports in animals, but contrasts with a previously reported study in humans. NPY is a 36 amino acid peptide neurotransmitter located in sympathetic and nonsympathetic nerve fibers, as well as in brain structures such as the locus coeruleus, where it is colocalized with norepinephrine. NPY has been shown to inhibit locus coeruleus neuronal firing, decrease norepinephrine release, and increase postsynaptic noradrenergic signal transduction. When administered centrally, NPY also has anxiolytic properties. This study therefore suggests that yohimbine challenge may be useful in assessing NPY and noradrenergic system interactions in neuropsychiatric disorders such as panic disorder or post traumatic stress disorder in which noradrenergic system dysfunction has been observed. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:04:47