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Titolo:
COMPARISON OF CEFTRIAXONE AND CEFOTAXIME IN SEVERE PEDIATRIC BACTERIAL-INFECTION - A MULTICENTRIC STUDY
Autore:
BEGUE P; ASTRUC J; FRANCOIS P; FLORET D;
Indirizzi:
HOP TROUSSEAU,26 AVE DOCTEUR NETTER F-75571 PARIS 12 FRANCE
Titolo Testata:
Medecine et maladies infectieuses
fascicolo: 4, volume: 28, anno: 1998,
pagine: 300 - 306
SICI:
0399-077X(1998)28:4<300:COCACI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
FRE
Soggetto:
MENINGITIS; THERAPY; CHILDREN; INFANTS; EFFICACY;
Keywords:
3RD GENERATION CEPHALOSPORIN; CEFTRIAXONE; PEDIATRIC; SEVERE INFECTIONS; HEALTH CARE COST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P. Begue et al., "COMPARISON OF CEFTRIAXONE AND CEFOTAXIME IN SEVERE PEDIATRIC BACTERIAL-INFECTION - A MULTICENTRIC STUDY", Medecine et maladies infectieuses, 28(4), 1998, pp. 300-306

Abstract

319 children with clinical data indicating a probably severe bacterial infection were randomly studied during 9 months in 33 French center. They were treated either with a single daily injection of ceftriaxoneat 50 mg/kg/d (100 mg/kg/d for meningitis or typhoid fever) or with 3to 4 injections of cefotaxime at 100 to 200 mg/kg/d. An aminoglycoside or an imidazole compound could be used as associated therapy according to the severity of infection as well as ampicillin in neonates. Theclinical severity criteria and the biological parameters (PCR) were assessed before antibiotic treatment. 233 cases were selected for the comparative study: 22 new-borns, 117 infants, 94 children. 118 were given ceftriaxone and 115 cefotaxime. The infections were documented for 221/233 patients (95 %): E. coli (54 %). H. influenzae (14 %). N. meningitidis (6 %), Proteus mirabilis (3,5 %), S. pneumoniae (6 %), Streptococci (2.6 %). Pseudomonas (2.2 %) Enterobacter (1.7 %). Salmonella typhi (6.7 %). miscellaneous (3.3 %). The infections treated were pyelonephritis (131), meningitis (36), septic fever (35), and other infections (31). The groups were comparable in age and sex. Results showed nodifference for efficacity or bacterial eradication, in any pathology. Tolerance was excellent for the two groups, adverse reactions were rare: 9 for the ceftriaxone group, 10 for the cefotaxime group (no significant difference). The total dose (mg/kg x days of treatment) of cefotaxime was three time higher than the total dose of ceftriaxone used. This trial stressed thr easier management and the potential lower costof ceftriaxone, thanks to 3 single daily administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:28:25