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Titolo:
SYNTHETIC REACTIONS WITH DIVALENT TITANIU M COMPLEX
Autore:
SATO F; URABE H; OKAMOTO S;
Indirizzi:
TOKYO INST TECHNOL,DEPT BIOMOL ENGN,FAC BIOSCI & BIOTECHNOL,MIDORI KU,4259 NAGATSUTA CHO YOKOHAMA KANAGAWA JAPAN
Titolo Testata:
Yuki Gosei Kagaku Kyokaishi
fascicolo: 5, volume: 56, anno: 1998,
pagine: 424 - 432
SICI:
0037-9980(1998)56:5<424:SRWDTM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
JPN
Soggetto:
NUCLEOPHILIC ACYL SUBSTITUTION; HIGHLY EFFICIENT SYNTHESIS; I-PRMGBR REAGENT; CARBONYL-COMPOUNDS; ALKYNE COMPLEXES; PRACTICAL SYNTHESIS; STEREOSELECTIVE SYNTHESIS; ALLYLTITANIUM COMPOUNDS; ALCOHOL DERIVATIVES; GRIGNARD-REAGENTS;
Keywords:
TITANIUM TETRAISOPROPOXIDE; GRIGNARD REAGENT; (ETA(2)-PROPENE)TI(O-I-PR)(2); (ETA(2)-ALKYNE)TI(O-I-PR)(2); LOW-VALENT TITANIUM COMPLEX; ALLYLTITANIUM COMPOUND; PROPARGYLTITANIUM COMPOUND; INTRAMOLECULAR NUCLEOPHILIC ACYL SUBSTITUTION REACTION; CYCLOMETALATION; CYCLIZATION; ASYMMETRIC SYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
F. Sato et al., "SYNTHETIC REACTIONS WITH DIVALENT TITANIU M COMPLEX", Yuki Gosei Kagaku Kyokaishi, 56(5), 1998, pp. 424-432

Abstract

Treatment of Ti(O-i-Pr)(4) with 2 equiv of i-PrMgX (X = Cl or Br) provides (eta(2)-propene) Ti(O-i-Pr)(2) in essentially quantitative yield. This new low-valent titanium complex nicely acts as a versatile titanium (II) equivalent to effect the following unique transformations. Thus, alkynes afforded titanium-alkyne complexes which, in turn, react with aldehydes, ketones, or imines to furnish the corresponding addition products. Allylic or propargylic compounds such as halides and alcohol derivatives gave allylic- or allenylic titanium species, which could be utilized in chemo-and diastereoselective reactions with carbonylcompounds. While acetylenic esters resulted in an intramolecular nucleophilic acyl substitution (INAS) reaction to provide unsaturated ketones, olefinic ones furnished cyclopropanols. 1,6- or 1,7-Dienes, enynes, and diynes underwent cyclometallation to give dialkoxytitanacycles,which show some distinctive reactivities among the metallacycles of early transition metal complexes. A few applications to natural productsynthesis by taking advantage of these methods are also illustrated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:08:20