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Titolo:
BLOCKADE OF VOLTAGE-OPERATED CALCIUM CHANNELS, INCREASE IN SPONTANEOUS CATECHOLAMINE RELEASE AND ELEVATION OF INTRACELLULAR CALCIUM LEVELS IN BOVINE CHROMAFFIN CELLS BY THE PLANT ALKALOID TETRANDRINE
Autore:
BICKMEYER U; WEINSBERG F; MULLER E; WIEGAND H;
Indirizzi:
MED INST UMWELTHYG,ABT NEUROTOXIKOL,HENNEKAMP 50 D-40225 DUSSELDORF GERMANY MED INST UMWELTHYG,ABT NEUROTOXIKOL D-40225 DUSSELDORF GERMANY
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 4, volume: 357, anno: 1998,
pagine: 441 - 445
SICI:
0028-1298(1998)357:4<441:BOVCCI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDICINAL HERB ORIGIN; CURRENTS; ENTRY; THAPSIGARGIN;
Keywords:
TETRANDRINE; CALCIUM CHANNEL CURRENTS; CATECHOLAMINE; INTRACELLULAR CALCIUM; THAPSIGARGIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
U. Bickmeyer et al., "BLOCKADE OF VOLTAGE-OPERATED CALCIUM CHANNELS, INCREASE IN SPONTANEOUS CATECHOLAMINE RELEASE AND ELEVATION OF INTRACELLULAR CALCIUM LEVELS IN BOVINE CHROMAFFIN CELLS BY THE PLANT ALKALOID TETRANDRINE", Naunyn-Schmiedeberg's archives of pharmacology, 357(4), 1998, pp. 441-445

Abstract

Experiments were performed in bovine chromaffin cells in short term primary culture. Tetrandrine is a plant alkaloid from the chinese medical herb Stefania tetrandra. The aim of the present study was to investigate the mechanisms by which tetrandrine interacts with calcium signalling and to provide a quantitative description of effects. Tetrandrine blocked voltage-operated calcium channel currents concentration-dependently as shown in whole cell patch-clamp recordings. The blockade ofcalcium channels reduced the potassium-stimulated catecholamine release. Besides, the drug increased the spontaneous (not stimulated) release of catecholamines in the presence of extracellular calcium. Measurements of intracellular calcium levels [Ca]i showed a calcium release from intracellular stores by tetrandrine. This tetrandrine-induced [Ca]i elevation was higher in calcium containing as compared to calcium free solution. Tetrandrine effects partially overlap with those of thapsigargin, but tetrandrine has additional targets, since it increased [Ca]i in cells pretreated with thapsigargin. We conclude that tetrandrine blocks voltage-operated calcium channels and increases [Ca]i by blocking endoplasmic and other calcium pumps.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:02:05