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Titolo:
SUPPRESSION OF ALLOREACTIVITY WITH GAMMA-DELTA-T-CELLS - RELEVANCE TOINCREASED GAMMA-DELTA-T-CELLS FOLLOWING BONE-MARROW TRANSPLANTATION
Autore:
NAGAI M; AZUMA E; QI J; KUMAMOTO T; HIRATAKE S; HIRAYAMA M; UMEMOTO M; KOMADA Y; SAKURAI M;
Indirizzi:
MIE UNIV,SCH MED,DEPT PEDIAT & CLIN IMMUNOL,2-174 EDOBASHI TSU MIE 514 JAPAN MIE UNIV,SCH MED,DEPT PEDIAT & CLIN IMMUNOL TSU MIE 514 JAPAN
Titolo Testata:
Biomedicine & pharmacotherapy
fascicolo: 3, volume: 52, anno: 1998,
pagine: 137 - 142
SICI:
0753-3322(1998)52:3<137:SOAWG->2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOBLASTIC-LEUKEMIA; ACTIVATED KILLER CELLS; PERIPHERAL-BLOOD; LYMPHOCYTES-T; HOST DISEASE; EXPRESSION; GENERATION;
Keywords:
GAMMA-DELTA T-CELL; VETO CELL; BONE MARROW TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Nagai et al., "SUPPRESSION OF ALLOREACTIVITY WITH GAMMA-DELTA-T-CELLS - RELEVANCE TOINCREASED GAMMA-DELTA-T-CELLS FOLLOWING BONE-MARROW TRANSPLANTATION", Biomedicine & pharmacotherapy, 52(3), 1998, pp. 137-142

Abstract

Several reports have shown that an increase in T-cell receptor gamma/delta-positive T-cells (gamma delta T-cells) have been observed following bone marrow transplantation. gamma delta T-cells expanded from peripheral blood mononuclear cells from normal volunteers were used to investigate the function of gamma delta T-cells in vitro. Peripheral blood mononuclear cells were cultured with synthetic ligand of gamma delta T-cells, monoethyl phosphates (MEP), for 7 days. MEP specifically expanded gamma delta T-cells. Expanded gamma delta T-cells from subject ''B'' were added to an A anti-B or A anti-C mixed lymphocyte culture (MLC) containing responder cells from subject ''A'' and irradiated stimulator cells from subjects ''B'' or ''C''. The cultures were harvestedon day 6 and tested for cytotoxicity against stimulator-type Con A blasts. gamma delta T-cells from subject ''B'' specifically inhibit generation of allospecific cytotoxic T lymphocytes (CTL) in A anti-B MLC. The results indicate that gamma delta T-cells exhibit veto-type suppression of alloreaction. If the current experiments are also applicable in vivo, gamma delta T-cells originating from the donor after bone marrow transplantation may inhibit graft rejection by suppressing recipient anti-donor reactivity. gamma delta T-cells may be involved in the suppression of allogeneic reaction in vivo following allogeneic bone marrow transplantation. (C) 1998 Elsevier, Paris.

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Documento generato il 29/03/20 alle ore 12:13:42