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Titolo:
RECOGNITION AND CONVERSION OF SINGLE-STRANDED AND DOUBLE-STRANDED OLIGONUCLEOTIDE SUBSTRATES BY 8-OXOGUANINE-DNA GLYCOSYLASE FROM ESCHERICHIA-COLI
Autore:
ISHCHENKO AA; BULYCHEV NV; MAKSAKOVA GA; JOHNSON F; NEVINSKY GA;
Indirizzi:
RUSSIAN ACAD SCI,NOVOSIBIRSK BIOORGAN CHEM INST,SIBERIAN DIV,UL LAVRENTEVA 8 NOVOSIBIRSK 630090 RUSSIA RUSSIAN ACAD SCI,NOVOSIBIRSK BIOORGAN CHEM INST,SIBERIAN DIV NOVOSIBIRSK 630090 RUSSIA SUNY STONY BROOK,DEPT PHARMACOL SCI STONY BROOK NY 11794
Titolo Testata:
Biochemistry
fascicolo: 2, volume: 62, anno: 1997,
pagine: 204 - 211
SICI:
0006-2979(1997)62:2<204:RACOSA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
APURINIC APYRIMIDINIC SITES; URACIL-DNA GLYCOSYLASE; 8-HYDROXYGUANINE 7,8-DIHYDRO-8-OXOGUANINE; DAMAGED DNA; FPG PROTEIN; RESIDUES; EXCISION; HYPOXANTHINE; SPECIFICITY; OLIGOMERS;
Keywords:
8-OXOGUANINE-DNA GLYCOSYLASE; SINGLE-STRANDED OLIGONUCLEOTIDES; SUBSTRATE SPECIFICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Ishchenko et al., "RECOGNITION AND CONVERSION OF SINGLE-STRANDED AND DOUBLE-STRANDED OLIGONUCLEOTIDE SUBSTRATES BY 8-OXOGUANINE-DNA GLYCOSYLASE FROM ESCHERICHIA-COLI", Biochemistry, 62(2), 1997, pp. 204-211

Abstract

The substrate specificity of 8-oxoguanine-DNA glycosylase was studied. The data showed for the first time that the enzyme can cleave single-stranded deoxyoligonucleotides containing an 8-oxoG link. The values of K-m and V-max for a range of single-stranded and double-stranded oligonucleotides (23 bp) containing 8-oxoG at different positions of onechain. These parameters consistently depended on the position of 8-oxoG in single-stranded or double-stranded substrates. A possible mechanism responsible for substrate recognition by 8-oxoguanine-DNA glycosylase is described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 19:19:49