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Titolo:
LOCALIZED PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN PATIENTS WITH ADULT ADRENOLEUKODYSTROPHY - INCREASE OF CHOLINE COMPOUNDS IN NORMAL-APPEARING WHITE-MATTER
Autore:
TOURBAH A; STIEVENART JL; IBAZIZEN MT; LUBETZKI C; BAUMANN N; EYMARD B; MOSER HW; LYONCAEN O; CABANIS EA;
Indirizzi:
CTR HOSP NATL OPHTALMOL 15 20,SERV NEURORADIOL,28 RUE CHARENTON F-75012 PARIS FRANCE KENNEDY KRIEGER INST,PEROXISOME DIS LAB BALTIMORE MD 00000 HOP BEAUJON,SERV BIOPHYS & MED NUCL CLICHY FRANCE HOP LA PITIE SALPETRIERE,NEUROL SERV PARIS FRANCE INSERM,U134 PARIS FRANCE INSERM,U360 PARIS FRANCE FEDERAT NEUROL PARIS FRANCE
Titolo Testata:
Archives of neurology
fascicolo: 5, volume: 54, anno: 1997,
pagine: 586 - 592
SICI:
0003-9942(1997)54:5<586:LPMSIP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-LINKED ADRENOLEUKODYSTROPHY; CHAIN FATTY-ACIDS; MR SPECTROSCOPY; HUMAN-BRAIN; RAT-BRAIN; ABNORMALITIES; GLUTAMATE; ASPARTATE; THERAPY; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Tourbah et al., "LOCALIZED PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN PATIENTS WITH ADULT ADRENOLEUKODYSTROPHY - INCREASE OF CHOLINE COMPOUNDS IN NORMAL-APPEARING WHITE-MATTER", Archives of neurology, 54(5), 1997, pp. 586-592

Abstract

Objectives: To describe the changes in the results of magnetic resonance imaging and spectroscopy occuring in the normal-appearing white matter of patients with adult adrenoleukodystrophy and to present evidence of a particular change that may serve as a marker for the follow-upof the disease. Design: Neurologic, magnetic resonance imaging, and localized proton spectroscopic examinations were performed in 11 patients with adult adrenoleukodystrophy and compared with 11 sex- and age-matched controls. Patients: Eleven patients with adult adrenoleukodystrophy participated in a trial of dietary therapy with glyceryl trioleate and glyceryl trierucate (Lorenzo's oil) in the Federation de Neurologie and the Institut National de la Sante et de la Recherche Medicale,Unite 134, at the Hopital de la Salpetriere in Paris, France. Results: The results of magnetic resonance imaging of the white matter were normal in 2 patients and showed areas of mild symmetrical hypersignals on T-2-weighted images and fluid attenuated inversion recovery sequences, localized in the posterior white matter in 9 patients. The resultsof spectroscopy indicated that the peak of the area of choline-containing compounds was increased at long echo times in patients with adultadrenoleukodystrophy, which may reflect very long-chain fatty acid accumulation in this disease. The peak of the area of myo-inositol-containing compounds was increased at short echo times in patients with adult adrenoleukodystrophy, which may indicate a rise in this metabolite concentration. The N-acetylaspartate-creatine amplitude ratio was significantly decreased in patients with motor deficit. The significance of this finding remains to be established. Conclusions: The results of localized proton magnetic resonance spectroscopy show abnormalities inthe cerebral white matter of patients with adult adrenoleukodystrophy, which may contribute to the understanding of the pathophysiologic characteristics of the disease. Although changes in the results of spectroscopy found in this disease are not specific, the increase of choline-containing compounds may reflect the accumulation of very long-chainfatty acids in the central nervous system. Localized proton magnetic resonance spectroscopy may prove a valuable technique, in addition to magnetic resonance imaging, for noninvasive investigation of patients with adult adrenoleukodystrophy undergoing future clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:34:13