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Titolo:
CIRCANNUAL VARIATIONS IN THE BINDING OF [H-3]LYSERGIC ACID DIETHYLAMIDE TO SEROTONIN(2A) RECEPTORS AND OF [H-3]PAROXETINE TO SEROTONIN UPTAKE SITES IN PLATELETS FROM HEALTHY-VOLUNTEERS
Autore:
SPIGSET O; ALLARD P; MJORNDAL T;
Indirizzi:
NORRLAND UNIV HOSP,DIV CLIN PHARMACOL S-90185 UMEA SWEDEN NORRLAND UNIV HOSP,DEPT PSYCHIAT S-90185 UMEA SWEDEN
Titolo Testata:
Biological psychiatry
fascicolo: 10, volume: 43, anno: 1998,
pagine: 774 - 780
SICI:
0006-3223(1998)43:10<774:CVITBO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; 5-HT UPTAKE SITES; BLOOD-PLATELETS; H-3-IMIPRAMINE BINDING; SEASONAL-VARIATION; DEPRESSED-PATIENTS; )H-3>IMIPRAMINE BINDING; SUICIDAL-BEHAVIOR; FRONTAL-CORTEX; HUMAN-BRAIN;
Keywords:
SEROTONIN; SEROTONIN RECEPTORS; SEROTONIN UPTAKE SITE; PLATELETS; CIRCANNUAL VARIATIONS; PAROXETINE; LYSERGIC ACID DIETHYLAMIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
O. Spigset et al., "CIRCANNUAL VARIATIONS IN THE BINDING OF [H-3]LYSERGIC ACID DIETHYLAMIDE TO SEROTONIN(2A) RECEPTORS AND OF [H-3]PAROXETINE TO SEROTONIN UPTAKE SITES IN PLATELETS FROM HEALTHY-VOLUNTEERS", Biological psychiatry, 43(10), 1998, pp. 774-780

Abstract

Background: Circannual variations occur in several serotonergic parameters, including platelet serotonin uptake and platelet [H-3]imipramine binding. Methods: Binding of [H-3]lysergic acid diethylamide ([H-3]LSD) to platelet serotonin (5-HT)(2A) receptors and binding of [H-3]paroxetine to platelet serotonin uptake sites were studied longitudinallyfor 1 year in 12 healthy volunteers. Results: For [H-3]LSD, the number of binding sites (B-max) showed no significant seasonal variation (two-way analysis of variance), although B-max was significantly higher during the months October through February than during the months April through August (32.6 vs. 29.8 fmol/mg protein; p = .015). For [H-3]paroxetine, B-max showed a significant seasonal variation (p = .003) with maximum in August (1322 fmol/mg protein) and minimum in February (1168 fmol/mg protein). The affinity constant (K-d) showed a significantseasonal variation for [H-3]LSD binding (p = .046), but not for [H-3]paroxetine binding. The seasonal fluctuations in [H-3]LSD binding and in paroxetine binding tended to be inversely correlated for B-max (r =-.70; p = .08) and were significantly negatively correlated for (r = -.88; P = .009). Conclusions: The present study demonstrates a seasonal effect on platelet serotonin uptake site binding and indicates a possible seasonal effect on 5-HT2A receptor binding. The results imply that circannual fluctuations should be taken into account when these platelet serotonin markers are studied (C) 1998 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:51:24