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Titolo:
EFFECTS OF LESIONS IN THE MESIAL FRONTAL-CORTEX ON BIMANUAL COORDINATION IN MONKEYS
Autore:
KAZENNIKOV O; HYLAND B; WICKI U; PERRIG S; ROUILLER EM; WIESENDANGER M;
Indirizzi:
UNIV BERN,INSELSPITAL,DEPT NEUROL,MOTOR SYST LAB,BHH-M130 CH-3010 BERN SWITZERLAND UNIV BERN,INSELSPITAL,DEPT NEUROL,MOTOR SYST LAB CH-3010 BERN SWITZERLAND RUSSIAN ACAD SCI,INST PROBLEMS INFORMAT TRANSMISS MOSCOW RUSSIA UNIV OTAGO,SCH MED,DEPT PHYSIOL DUNEDIN NEW ZEALAND KANTONSSPITAL,DEPT NEUROL CH-4031 BASEL SWITZERLAND HOP UNIV GENEVE,DEPT NEUROL CH-1205 GENEVA SWITZERLAND UNIV FRIBOURG,INST PHYSIOL CH-1700 FRIBOURG SWITZERLAND
Titolo Testata:
Neuroscience
fascicolo: 3, volume: 85, anno: 1998,
pagine: 703 - 716
SICI:
0306-4522(1998)85:3<703:EOLITM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPLEMENTARY MOTOR AREA; MEDIAL PREMOTOR CORTEX; LEARNED MOVEMENTS; NEURONAL-ACTIVITY; CEREBRAL-CORTEX; ACTIVATION;
Keywords:
MOTOR EQUIVALENCE PRINCIPLE; BIMANUAL COORDINATION; MOVEMENT INITIATION; SUPPLEMENTARY MOTOR AREA; LESION; MONKEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
O. Kazennikov et al., "EFFECTS OF LESIONS IN THE MESIAL FRONTAL-CORTEX ON BIMANUAL COORDINATION IN MONKEYS", Neuroscience, 85(3), 1998, pp. 703-716

Abstract

The hypothesis was tested that the mesial frontal cortex, including the supplementary motor area, is engaged in bimanual co-ordination. Three monkeys, trained in a well-co-ordinated bimanual pull-and-grasp task, were subjected to unilateral or bilateral lesions of the mesial frontal cortex. With unilateral lesions, the deficit consisted in a delayin movement initiation of the contralateral arm. With a bilateral lesion, the deficit was more pronounced with marked bilateral delays in movement onset and slowing in reaching. However, in the three monkeys bimanual co-ordination at the moment of goal achievement remained intact with an excellent temporal co-variation of the two limbs. In the twounilateral cases, an adaptive strategy developed after a few sessions, either by catching up during reaching with the limb contralateral tothe lesion (monkey M1) or by delaying movement initiation of the limbipsilateral to the lesion (monkey M2). This outcome is discussed in terms of Lashley's principle of motor equivalence, i.e. invariant goal achievement with variable means. Bilateral lesions led to a transient and near-total impairment in movement self-initiation when all external cues were absent. It is concluded that in monkeys the mesial frontalcortex does not play a crucial role in bimanual co-ordination but rather in movement initiation, especially when sensory cues are absent. (C) 1998 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 04/12/20 alle ore 16:21:16