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Titolo:
GENETIC DISSECTION OF OLETF, A RAT MODEL FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS
Autore:
KANEMOTO N; HISHIGAKI H; MIYAKITA A; OGA K; OKUNO S; TSUJI A; TAKAGI T; TAKAHASHI E; NAKAMURA Y; WATANABE TK;
Indirizzi:
OTSUKA PHARMACEUT CO LTD,OTSUKA GEN RES INST,463-10 KAGASUNO KAWAUCHITOKUSHIMA 77101 JAPAN UNIV TOKYO,INST MED SCI,MOL MED LAB,MINATO KU TOKYO 108 JAPAN UNIV TOKYO,INST MED SCI,CTR HUMAN GENOME,LAB GENOME DATABASE,MINATO KU TOKYO 108 JAPAN
Titolo Testata:
Mammalian genome
fascicolo: 6, volume: 9, anno: 1998,
pagine: 419 - 425
SICI:
0938-8990(1998)9:6<419:GDOOAR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOKUSHIMA FATTY RAT; DIABETOGENIC GENE; LINKAGE MAPS; GK RAT; CHROMOSOME; MUTATIONS; DEFECT; TRAITS; LOCI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
N. Kanemoto et al., "GENETIC DISSECTION OF OLETF, A RAT MODEL FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS", Mammalian genome, 9(6), 1998, pp. 419-425

Abstract

To elucidate the genetic factors underlying non-insulin-dependent diabetes mellitus (NIDDM), we performed genome-wide quantitative trait locus (QTL) analysis, using the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF rat is an excellent animal model of NIDDM because thefeatures of the disease closely resemble human NIDDM. Genetic dissection with two kinds of F2 intercross progeny, from matings between the OLETF rat and non-diabetic control rats F344 or BN, allowed us to identify on Chromosome (Chr) 1 a major QTL associated with features of NIDDM that was common to both crosses. We also mapped two additional significant loci, on Chrs 7 and 14, in the (OLETF x F344)F-2 cross alone, and designated these three loci as Diabetes mellitus, OLETF type Dmo 1, Dmo2 and Dmo3 respectively. With regard to suggestive QTLs, we foundloci on Chrs 10, 11, and 16 that were common to both crosses, as wellas loci on Chrs 5 and 12 in the (OLETF x F344)F-2 cross and on Chrs 4and 13 in the (OLETF x BN)F-2 cross. Our results showed that NIDDM inthe OLETF rat is polygenic and demonstrated that different genetic backgrounds could affect ''fitness'' for QTLs and produce different phenotypic effects from the same locus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:35:09