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Titolo:
RANDOMIZED TRIAL OF EFFECTS OF VITAMIN SUPPLEMENTS ON PREGNANCY OUTCOMES AND T-CELL COUNTS IN HIV-1-INFECTED WOMEN IN TANZANIA
Autore:
FAWZI WW; MSAMANGA GI; SPIEGELMAN D; URASSA EJN; MCGRATH N; MWAKAGILE D; ANTELMAN G; MBISE R; HERRERA G; KAPIGA S; WILLETT W; HUNTER DJ;
Indirizzi:
HARVARD UNIV,SCH PUBL HLTH,DEPT NUTR,665 HUNTINGTON AVE BOSTON MA 02115 HARVARD UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL BOSTON MA 02115 HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT BOSTON MA 02115 MUHIMBILI UNIV,COLL HLTH SCI,DEPT COMMUNITY HLTH DAR ES SALAAM TANZANIA MUHIMBILI UNIV,COLL HLTH SCI,DEPT OBSTET & GYNECOL DAR ES SALAAM TANZANIA MUHIMBILI UNIV,COLL HLTH SCI,DEPT MICROBIOL & IMMUNOL DAR ES SALAAM TANZANIA MUHIMBILI UNIV,COLL HLTH SCI,DEPT PEDIAT & CHILD HLTH DAR ES SALAAM TANZANIA MUHIMBILI UNIV,COLL HLTH SCI,DEPT EPIDEMIOL & BIOSTAT DAR ES SALAAM TANZANIA
Titolo Testata:
Lancet
fascicolo: 9114, volume: 351, anno: 1998,
pagine: 1477 - 1482
SICI:
0140-6736(1998)351:9114<1477:RTOEOV>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; HIV-INFECTION; INFANT-MORTALITY; TYPE-1 INFECTION; BETA-CAROTENE; BIRTH-WEIGHT; A-DEFICIENCY; MORBIDITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
W.W. Fawzi et al., "RANDOMIZED TRIAL OF EFFECTS OF VITAMIN SUPPLEMENTS ON PREGNANCY OUTCOMES AND T-CELL COUNTS IN HIV-1-INFECTED WOMEN IN TANZANIA", Lancet, 351(9114), 1998, pp. 1477-1482

Abstract

Background. In HIV-1-infected women, poor micronutrient status has been associated with faster progression of HIV-1 disease and adverse birth outcomes. We assessed the effects of vitamin A and multivitamins onbirth outcomes in such women. Methods. In Tanzania, 1075 HIV-1-infected pregnant women at between 12 and 27 weeks' gestation received placebo (n = 267), vitamin A (n = 269), multivitamins excluding vitamin A (n = 269), or multivitamins including vitamin A (n = 270) in a randomised, double-blind, placebo-controlled trial with a 2x2 factorial design. We measured the effects of multivitamins and vitamin A on birth outcomes and counts of T lymphocyte subsets. We did analyses by intention to treat.Results. 30 fetal deaths occurred among women assigned multivitamins compared with 49 among those not on multivitamins (relative risk 0.61 [95% CI 0.39-0.94] p = 0.02). Multivitamin supplementation decreased the risk of low birthweight (< 2500 g) by 44% (0.56 [0.38-0.82]p = 0.003), severe preterm birth (< 34 weeks of gestation) by 39% (0.61 [0.38-0.96] p = 0.03), and small size for gestational age at birth by 43% (0.57 [0.39-0.82] p = 0.002). Vitamin A supplementation had no significant effect on these variables. Multivitamins, but not vitamin A, resulted in a significant. increase in CD4, CD8, and CD3 counts. Interpretation. Multivitamin supplementation is a low-cost way of substantially decreasing adverse pregnancy outcomes and increasing T-cell counts in HIV-l-infected women. The clinical relevance of our findings for vertical transmission and clinical progression of HIV-1 disease is yet to be ascertained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:41:47