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Titolo:
IN-VIVO AND IN-VITRO HEPATIC P-31 MAGNETIC-RESONANCE SPECTROSCOPY ANDELECTRON-MICROSCOPY IN CHRONIC DUCTOPENIC REJECTION OF HUMAN LIVER ALLOGRAFTS
Autore:
TAYLORROBINSON SD; SARGENTONI J; BELL JD; THOMAS EL; MARCUS CD; CHANGANI KK; SAEED N; HODGSON HJF; DAVIDSON BR; BURROUGHS AK; ROLLES K; FOSTER CS; COX IJ;
Indirizzi:
HAMMERSMITH HOSP,SCH MED,IMPERIAL COLL,ROBERT STEINER MR UNIT,DU CANERD LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,SCH MED,IMPERIAL COLL,GASTROENTEROL UNIT LONDON W12 0NN ENGLAND UNIV LONDON,DEPT SURG,ROYAL FREE HOSP LONDON ENGLAND UNIV LONDON,DEPT MED,ROYAL FREE HOSP LONDON ENGLAND UNIV LONDON SCH MED LONDON ENGLAND UNIV LIVERPOOL,DEPT PATHOL LIVERPOOL L69 3BX MERSEYSIDE ENGLAND
Titolo Testata:
Gut
fascicolo: 5, volume: 42, anno: 1998,
pagine: 735 - 743
SICI:
0017-5749(1998)42:5<735:IAIHPM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILE-DUCT SYNDROME; IN-VITRO; P-31; INVIVO; CIRRHOSIS; DISEASE; METABOLITES; FEATURES; CANCER; BRAIN;
Keywords:
IN VIVO P-31 MAGNETIC RESONANCE SPECTROSCOPY; IN VITRO P-31 MAGNETIC RESONANCE SPECTROSCOPY; LIVER TRANSPLANTATION; CHRONIC DUCTOPENIC REJECTION; ELECTRON MICROSCOPY; PHOSPHOLIPIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S.D. Taylorrobinson et al., "IN-VIVO AND IN-VITRO HEPATIC P-31 MAGNETIC-RESONANCE SPECTROSCOPY ANDELECTRON-MICROSCOPY IN CHRONIC DUCTOPENIC REJECTION OF HUMAN LIVER ALLOGRAFTS", Gut, 42(5), 1998, pp. 735-743

Abstract

Background-In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (MRS) provides non-invasive information about phospholipid metabolism. Aims-To delineate MRS abnormalities in patients with chronic ductopenic rejection (CDR) and to characterise spectral changes by in vitro MRS and electron microscopy. Patients and methods-Sixteen liver transplant recipients (four with CDR; 12 with good graft function) and 29 controls (23 healthy volunteers; six patients with biliary duct strictures) were studied with in vivo P-31 MRS Peak area ratios of phosphomonoesters (PME) and phosphodiesters (PDE), relative to nucleotide triphosphates (NTP) were measured. In vitro MRS and electron microscopy were performed on biopsy specimens from five patients with CDR, freeze clamped at retransplantation. Phosphoethanolamine (PE), phosphocholine (PC), glycerophosphorylethanolamine (GPE), and glycerophosphorylcholine(GPC) concentrations were measured. Results-The 12 patients with goodgraft function displayed no spectral abnormalities in vivo; the four patients with CDR showed significantly elevated PME:NTP (p<0.01) and PDE:NTP ratios (p<0.005). Patients with biliary strictures had significant differences in PME:NTP (p<0.01) from patients with CDR, but not inmean PDE:NTP. In vitro spectra from CDR patients showed elevated PE and PC, mirroring the in vivo changes in PME, but reduced GPE and GPC concentrations were observed, at variance with the in vivo PDE findings. On electron microscopy, there was no proliferation in hepatocyte endoplasmic reticulum. Conclusions-The increase in PME:NTP reflects altered phospholipid metabolism in patients with CDR, while the increase inPDE:NTP may represent a significant contribution from bile phospholipid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:21:16