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Titolo:
PLASMA-LEVELS OF R-SALSOLINOL AND S-SALSOLINOL ARE NOT INCREASED IN DE-NOVO PARKINSONIAN-PATIENTS
Autore:
MULLER T; BAUM SS; HAUSSERMANN P; WOITALLA D; ROMMELSPACHER H; PRZUNTEK H; KUHN W;
Indirizzi:
RUHR UNIV BOCHUM,ST JOSEF HOSP,DEPT NEUROL,GUDRUNSTR 56 D-44791 BOCHUM GERMANY FREE UNIV BERLIN,BENJAMIN FRANKLIN HOSP,DEPT CLIN NEUROBIOL BERLIN GERMANY
Titolo Testata:
Journal of neural transmission
fascicolo: 2-3, volume: 105, anno: 1998,
pagine: 239 - 246
SICI:
0300-9564(1998)105:2-3<239:PORASA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENANTIOMERIC COMPOSITION; DOPAMINERGIC NEUROTOXIN; CEREBROSPINAL-FLUID; URINARY SALSOLINOL; ALCOHOLICS; N-METHYL(R)SALSOLINOL; DISEASE; BRAIN; NONALCOHOLICS; ISOQUINOLINE;
Keywords:
SALSOLINOL; PARKINSONS DISEASE; N-METHYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T. Muller et al., "PLASMA-LEVELS OF R-SALSOLINOL AND S-SALSOLINOL ARE NOT INCREASED IN DE-NOVO PARKINSONIAN-PATIENTS", Journal of neural transmission, 105(2-3), 1998, pp. 239-246

Abstract

An augmented synthesis of tetrahydroisoquinolines, such as salsolinol(SAL) or an increased N-methylation of these compounds has been addressed by various investigators as putative pathophysiologic mechanisms in Parkinson's disease (PD). Aim of this study was (1) to investigate putative relations between plasma levels of dopamine and R-and S-enantiomers of SAL and (2) whether these metabolic precursors of the neurotoxic N-methylated-SAL (NMSAL) are elevated in untreated ''de-novo'' Parkinsonian patients compared to age-and sex-matched healthy controls. Plasma levels of R-and S-SAL and dopamine did not significantly (R-SAL: p = 0.61, S-SAL: p = 0.51, dopamine: p = 0.84) differ in both groups. Parkinsonian patients' R-SAL plasma levels were inversely related tointensity (p = 0.03, r = -0.42) and duration of PD (p = 0.03, r = -0.43) in contrast to S-SAL and dopamine. Dopamine levels were not associated to R-SAL (p = 0.88, r(2) = 0.0008) and S-SAL (p = 0.088, r(2) = 0.12) neither in Parkinsonian patients nor in controls. We conclude, that an upregulation of N-methylation of tetrahydroisoquinolines takes place in PD by enzymes such as neutral N-methyltransferase specific forR-SAL. The activity of this enzyme has been found elevated in parkinsonian lymphocytes. This increased N-methylation by the N-methyltransferase specific for R-SAL leads to the known augmented levels of neurotoxic R-NMSAL in Parkinsonian patients compared to controls in the cenral nervous system especially in the beginning of PD.

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Documento generato il 08/07/20 alle ore 06:33:36