Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SERTINDOLE AND DOPAMINE D-2 RECEPTOR OCCUPANCY IN COMPARISON TO RISPERIDONE, CLOZAPINE AND HALOPERIDOL - A I-123 IBZM SPECT STUDY
Autore:
KASPER S; TAUSCHER J; KUFFERLE B; BARNAS C; HESSELMANN B; ASENBAUM S; PODREKA I; BRUCKE T;
Indirizzi:
UNIV VIENNA,DEPT GEN PSYCHIAT,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,DEPT GEN NEUROL A-1090 VIENNA AUSTRIA KRANKENANSTLAT RUDOLFSTIFTUNG,DEPT NEUROL VIENNA AUSTRIA
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 136, anno: 1998,
pagine: 367 - 373
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON-EMISSION TOMOGRAPHY; IN-VIVO; SCHIZOPHRENIC-PATIENTS; NEUROLEPTICS; BLOCKADE; SCALE; RATS;
Keywords:
SERTINDOLE; CLOZAPINE; HALOPERIDOL; RISPERIDONE; DOPAMINE; D-2 RECEPTOR; SINGLE PHOTON EMISSION COMPUTERIZED TOMOGRAPHY (SPECT); ATYPICAL ANTIPSYCHOTIC DRUG (NEUROLEPTIC);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
S. Kasper et al., "SERTINDOLE AND DOPAMINE D-2 RECEPTOR OCCUPANCY IN COMPARISON TO RISPERIDONE, CLOZAPINE AND HALOPERIDOL - A I-123 IBZM SPECT STUDY", Psychopharmacology, 136(4), 1998, pp. 367-373

Abstract

The striatal D-2 dopamine binding was studied in schizophrenic patients treated with the novel atypical antipsychotic drug sertindole (n = 10). Comparisons were obtained with haloperidol (n = 8), clozapine (n = 6), risperidone (n = 11) and untreated healthy controls (n 8) of a dataset which has partly been reported previously. I-123-Iodobenzamide (IBZM) single photon emission computerized tomography (SPECT) was usedfor estimation of striatal dopamine D-2 receptor binding. Sertindole-treated patients exhibited significantly (P < 0.001) lower levels of striatal D-2 binding (BG/FC ratio:1.28) compared with those treated with haloperidol (BG/FC ratio:1.09) and risperidone (8 mg:1.18) but significantly (P < 0.005) higher levels compared with clozapine (BG/FC ratio:1.49). However, if patients were pretreated with a depot neuroleptic, significantly (P < 0.05) higher striatal D-2 binding (BG/FC ratio: 1.12) has been obtained. Since sertindole has been shown to exert distinct clinical efficacy for treatment of positive and negative symptoms,our data are indicative that antipsychotic efficacy is not associatedwith a high degree of striatal D-2 receptor occupancy in schizophrenic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/19 alle ore 04:27:17