Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THROMBOLYTIC THERAPY DOES NOT CHANGE THE RELEASE RATIOS OF ENZYMATIC AND NONENZYMATIC MYOCARDIAL MARKER PROTEINS
Autore:
WODZIG KWH; KRAGTEN JA; MODRZEJEWSKI W; GORSKI J; VANDIEIJENVISSER MP; GLATZ JFC; HERMENS WT;
Indirizzi:
UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT,POB 616 NL-6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT NL-6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,ACAD HOSP MAASTRICHT,DEPT CLIN CHEM MAASTRICHT NETHERLANDS HOSP DE WEVER GREGORIUS,DEPT CARDIOL HEERLEN NETHERLANDS MED ACAD BIALYSTOK,DEPT CARDIOL BIALYSTOK POLAND MED ACAD BIALYSTOK,DEPT PHYSIOL BIALYSTOK POLAND
Titolo Testata:
Clinica chimica acta
fascicolo: 2, volume: 272, anno: 1998,
pagine: 209 - 223
SICI:
0009-8981(1998)272:2<209:TTDNCT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY REPERFUSION; LEFT-VENTRICULAR FUNCTION; ACID-BINDING PROTEIN; CREATINE KINASE-MB; INFARCT SIZE; INTRAVENOUS STREPTOKINASE; CONVENTIONAL TREATMENT; LACTATE-DEHYDROGENASE; MYOGLOBIN; PLASMA;
Keywords:
FATTY ACID-BINDING PROTEIN; MYOGLOBIN; CREATINE KINASE; LACTATE DEHYDROGENASE; INFARCT SIZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K.W.H. Wodzig et al., "THROMBOLYTIC THERAPY DOES NOT CHANGE THE RELEASE RATIOS OF ENZYMATIC AND NONENZYMATIC MYOCARDIAL MARKER PROTEINS", Clinica chimica acta, 272(2), 1998, pp. 209-223

Abstract

Measurements of cardiac marker proteins in plasma from patients with acute myocardial infarction (AMI) have become important in the evaluation of recanalization therapy. The validity of this approach has however been questioned, because it was claimed that coronary reperfusion may increase the recovery in plasma of cardiac enzymes, such as creatine kinase (CK). In the present study, possible effects of thrombolytic therapy on the release of enzymatic and nonenzymatic marker proteins were investigated. Activities of CK and lactate dehydrogenase (LDH), and concentrations of myoglobin (Mb) and fatty acid-binding protein (FABP) were determined in serial plasma samples obtained from 50 patients with confirmed AMI, of whom 36 received thrombolytic therapy, and 14 did not. Treatment delay was 2.8+/-1.6 (mean+/-SD) h, and hospital delay in untreated patients was 2.7+/-1.8 h. Average infarct size, expressed in gram-equivalents of heart muscle per litre of plasma (g-eq/l), varied between 5.5 and 7.2 g-eq/l for the four marker proteins in patients treated with thrombolytic therapy, and between 4.6 and 6.4 g-eq/l in untreated patients, with a tendency to larger infarct sizes for Mb and FABP than for CK and LDH. Thrombolytic therapy, although significantly accelerating protein release rates, did not influence the releaseratios. These results indicate that thrombolytic therapy has no significant effects on the recovery of cardiac marker proteins in plasma. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 18:10:12