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Titolo:
THE EFFECTS OF SEX STEROIDS ON PLASMA-LEVELS OF MARKER PROTEINS OF ENDOTHELIAL-CELL FUNCTIONING
Autore:
VANKESTEREN PJM; KOOISTRA T; LANSINK M; VANKAMP GJ; ASSCHEMAN H; GOOREN LJG; EMEIS JJ; VISCHER UM; STEHOUWER CDA;
Indirizzi:
VRIJE UNIV AMSTERDAM,ACAD HOSP,DEPT INTERNAL MED,DE BOELELAAN 1117 NL-1081 HV AMSTERDAM NETHERLANDS VRIJE UNIV AMSTERDAM,ACAD HOSP,DEPT INTERNAL MED NL-1081 HV AMSTERDAMNETHERLANDS VRIJE UNIV AMSTERDAM,ACAD HOSP,DEPT ANDROL NL-1081 HV AMSTERDAM NETHERLANDS VRIJE UNIV AMSTERDAM,ACAD HOSP,DEPT CLIN CHEM NL-1081 HV AMSTERDAM NETHERLANDS TNO,IVVO,GAUBIUS LAB,PG NL-2300 AK LEIDEN NETHERLANDS UNIV GENEVA,HOP CANTONAL,DEPT INTERNAL MED CH-1211 GENEVA SWITZERLAND
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 5, volume: 79, anno: 1998,
pagine: 1029 - 1033
SICI:
0340-6245(1998)79:5<1029:TEOSSO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ACTIVATOR T-PA; PLASMINOGEN-ACTIVATOR; VONWILLEBRAND-FACTOR; MYOCARDIAL-INFARCTION; ORAL-CONTRACEPTIVES; ESTROGEN; RISK; MEN; FIBRINOLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
P.J.M. Vankesteren et al., "THE EFFECTS OF SEX STEROIDS ON PLASMA-LEVELS OF MARKER PROTEINS OF ENDOTHELIAL-CELL FUNCTIONING", Thrombosis and haemostasis, 79(5), 1998, pp. 1029-1033

Abstract

We studied thirteen male-to-female (M-->F) and ten female-to-male (F-->M) transsexuals who, for four months, received cross-sex treatment with, respectively, ethinylestradiol and cyproterone acetate, and with testosterone esters. We assessed the effects of treatment on plasma levels of tissue-type plasminogen activator (tPA), von Willebrand factor(VWF), vWF-propeptide (vWF:AgII) and big-endothelin-1 (big-ET-l)? four proteins that are markers of endothelial cell functioning. We also measured urokinase-type PA (uPA) and plasminogen activator inhibitor-type 1 (PAI-1), which may not be endothelium-derived but share major clearance pathways with tPA. In M-->F transsexuals, mean plasma levels oftPA (minus 4.4 ng/ml), big-ET-l (minus 0.8 pg/ml), uPA (minus 0.5 ng/ml) and PAI-1 (minus 26 ng/ml) decreased tall Ps less than or equal to0.02). The level of vWF increased (plus 24%; P = 0.005), while vWF:AgII did not change (P = 0.49). In F-->M transsexuals, levels of big-ET-l increased (plus 0.4 pg/ml; P = 0.02), while tPA, uPA and PAI-I did not change tall Ps >0.25). In this group vWF decreased (minus 14%; P = 0.06). but vWF:AgII did not change (P = 0.38). Estrogens and androgenshave clear effects on plasma levels of endothelial marker proteins. The mechanisms behind these effects are complex and appear to involve both altered secretion (big-ET-l) and processing and/or clearance (vWF and possibly tPA). Therefore, effects of hormones on the levels of endothelial marker proteins do nor necessarily reflect changes in endothelial cell functioning, at least with regard to changes in vWF level associated with the oral administration of high doses of ethinylestradiol and cyproterone acetate to healthy men and the parenteral administration of testosterone to healthy women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:32:25