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Titolo:
FACTOR-V-LEIDEN IS NOT A RISK FACTOR FOR ARTERIAL VASCULAR-DISEASE INTHE ELDERLY - RESULTS FROM THE CARDIOVASCULAR-HEALTH-STUDY
Autore:
CUSHMAN M; ROSENDAAL FR; PSATY BM; COOK EF; VALLIERE J; KULLER LH; TRACY RP;
Indirizzi:
UNIV VERMONT,LAB CLIN BIOCHEM RES,DEPT PATHOL,55A SOUTH PK DR COLCHESTER VT 05446 UNIV VERMONT,DEPT MED BURLINGTON VT 00000 UNIV VERMONT,DEPT PATHOL BURLINGTON VT 00000 UNIV LEIDEN HOSP,DEPT CLIN EPIDEMIOL LEIDEN NETHERLANDS UNIV LEIDEN HOSP,DEPT HEMATOL LEIDEN NETHERLANDS UNIV WASHINGTON,DEPT MED SEATTLE WA 00000 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 00000 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 00000 HARVARD UNIV,DEPT MED BOSTON MA 02115 HARVARD UNIV,DEPT PREVENT HLTH BOSTON MA 02115 UNIV VERMONT,DEPT PATHOL BURLINGTON VT 05405 UNIV PITTSBURGH,DEPT EPIDEMIOL PITTSBURGH PA 15261
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 5, volume: 79, anno: 1998,
pagine: 912 - 915
SICI:
0340-6245(1998)79:5<912:FINARF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-C; COAGULATION-FACTOR-V; VENOUS THROMBOSIS; RESISTANCE; MUTATION; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Cushman et al., "FACTOR-V-LEIDEN IS NOT A RISK FACTOR FOR ARTERIAL VASCULAR-DISEASE INTHE ELDERLY - RESULTS FROM THE CARDIOVASCULAR-HEALTH-STUDY", Thrombosis and haemostasis, 79(5), 1998, pp. 912-915

Abstract

Coagulation factor V Leiden is a risk marker for venous thrombosis. For arterial thrombosis no large study to date has included population-based elderly patients. The Cardiovascular Health Study is a longitudinal study of 5,201 men and women over age 65. With 3.4-year follow-up,we studied 373 incident cases of myocardial infarction (MI), angina, stroke, or transient ischemic attack (TIA), and 482 controls. The oddsratios for each event with heterozygous factor V Leiden were: MI, 0.46 (95% CI 0.17 to 1.25); angina, 1.0 (95% CI 0.45 to 2.23); stroke, 0.77 (95% CI 0.35 to 1.70), TIA, 1.33 (95% CI 0.5 to 3.55); any outcome,0.83 (95% CI 0.48 to 1.44). Adjustment for cardiovascular risk factors did not change relationships. In older adults factor V Leiden is nota risk factor for future arterial thrombosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:25:55