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Titolo:
CURRENT STATUS OF GENETIC-STUDIES OF GILLES-DE-LA-TOURETTE-SYNDROME
Autore:
BARR CL; SANDOR P;
Indirizzi:
TORONTO HOSP,WESTERN DIV,DEPT PSYCHIAT,399 BARTHURST ST,ROOM MP14-302TORONTO ON M5T 2S8 CANADA HOSP SICK CHILDREN,DEPT PSYCHIAT TORONTO ON M5G 1X8 CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON CANADA
Titolo Testata:
Canadian journal of psychiatry
fascicolo: 4, volume: 43, anno: 1998,
pagine: 351 - 357
SICI:
0706-7437(1998)43:4<351:CSOGOG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT HYPERACTIVITY; OBSESSIVE-COMPULSIVE DISORDER; DOPAMINE-D3 RECEPTOR GENE; NEUROPSYCHIATRIC DISORDERS; LINKAGE DISEQUILIBRIUM; PSYCHIATRIC-DISORDERS; TYROSINE-HYDROXYLASE; SEGREGATION ANALYSIS; NOVELTY SEEKING; NO EVIDENCE;
Keywords:
TOURETTE SYNDROME; GENETICS; LINKAGE; OBSESSIVE-COMPULSIVE DISORDER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Barr e P. Sandor, "CURRENT STATUS OF GENETIC-STUDIES OF GILLES-DE-LA-TOURETTE-SYNDROME", Canadian journal of psychiatry, 43(4), 1998, pp. 351-357

Abstract

Gilles de la Tourette syndrome (TS) is a familial, neuropsychiatric disorder characterized by chronic, intermittent motor and vocal ties. Despite strong evidence for a genetic basis of this disorder from family, twin, and adoption studies, no convincing evidence for genetic linkage has been reported. Numerous groups world-wide have searched for genetic susceptibility factors for TS, testing specific candidate genes in neurotransmitter systems as well as DNA markers with known locations. Several factors may complicate the search for genes for this disorder, including diagnostic uncertainties, definition of the TS phenotypic spectrum as it relates to genetic susceptibility, assortative mating, genetic heterogeneity, and unclear mode of inheritance. In this article, we review the evidence for the genetic basis of TS and the current status of genetic studies.

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Documento generato il 11/07/20 alle ore 20:46:56