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Titolo:
STEREO - A PROGRAM ON A PC-WINDOWS-95 PLATFORM FOR RECORDING AND EVALUATING QUANTITATIVE STEREOLOGIC INVESTIGATIONS OF MULTISTAGE HEPATOCARCINOGENESIS IN RODENTS
Autore:
XU YH; DRAGAN YP; CAMPBELL HA; PITOT HC;
Indirizzi:
UNIV WISCONSIN,SCH MED,MCARDLE LAB CANC RES,DEPT ONCOL MADISON WI 53706 UNIV WISCONSIN,SCH MED,MCARDLE LAB CANC RES,DEPT ONCOL MADISON WI 53706 UNIV WISCONSIN,SCH MED,MCARDLE LAB CANC RES,DEPT LAB MED & PATHOL MADISON WI 53706
Titolo Testata:
Computer methods and programs in biomedicine
fascicolo: 1, volume: 56, anno: 1998,
pagine: 49 - 63
SICI:
0169-2607(1998)56:1<49:S-APOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALTERED HEPATIC FOCI; RAT-LIVER; MOUSE-LIVER; CARCINOGENESIS; INITIATION; DIETHYLNITROSAMINE; PROMOTION; INDUCTION;
Keywords:
QUANTITATIVE STEREOLOGY; MULTISTAGE CHEMICAL CARCINOGENESIS; RAT LIVER; ALTERED HEPATIC FOCI; TUMOR PROMOTION; TUMOR PROGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
Y.H. Xu et al., "STEREO - A PROGRAM ON A PC-WINDOWS-95 PLATFORM FOR RECORDING AND EVALUATING QUANTITATIVE STEREOLOGIC INVESTIGATIONS OF MULTISTAGE HEPATOCARCINOGENESIS IN RODENTS", Computer methods and programs in biomedicine, 56(1), 1998, pp. 49-63

Abstract

The most common organ site of neoplasms induced by carcinogenic chemicals in the rodent bioassay is the liver. The development of cancer inrodent liver is a multistage process involving sequentially the stages of initiation, promotion, and progression. During the stages of promotion and progression, numerous lesions termed altered hepatic foci (AHF) develop. STEREO was developed for the purpose of efficient and accurate quantitation of AHF and related lesions in experimental and testrodents. The system utilized is equipped with a microcomputer (IBM-compatible PC running Windows 95) and a Summagraphics MICROGRID or SummaSketch tablet digitizer. The program records information from digitization of single or serial sections obtained randomly from rat liver tissue. With this information and the methods of quantitative stereology,both the number and volume percentage fraction of AHF in liver are calculated in three dimensions. The recorded data files can be printed graphically or in the format of tabular numerical data. The results of stereologic calculations are stored on floppy disks and can be sorted into different categories and analyzed or displayed with the use of statistics and graphic functions built into the overall program. Resultsmay also be exported into Microsoft Excel for use at a later time. Any IBM-compatible PC capable of utilizing Windows 95 and MS Office can be used with STEREO, which offers inexpensive, easily operated software to obtain three-dimensional information from sections of two dimensions for the identification and relative potency of initiators, promoters, and progressors, and for the establishment of information potentially useful in developing estimations of risk for human cancer. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 03/12/20 alle ore 15:41:24