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Titolo:
EXPRESSION OF BCL-2 IN FETAL THYMUS, THYMOMAS AND THYMIC CARCINOMAS -ASSOCIATION WITH P53 EXPRESSION AND REVIEW OF THE LITERATURE
Autore:
ENGEL P; FRANCIS D; GRAEM N;
Indirizzi:
NAKSKOVVEJ 108 DK-2500 VALBY DENMARK UNIV COPENHAGEN,DEPT PATHOL DK-1168 COPENHAGEN DENMARK UNIV COPENHAGEN,ROSKILDE AMTSSYGEHUS DK-1168 COPENHAGEN DENMARK UNIV COPENHAGEN,BISPEBJERG HOSP DK-1168 COPENHAGEN DENMARK UNIV COPENHAGEN,RIGSHOSP DK-1168 COPENHAGEN DENMARK
Titolo Testata:
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica
fascicolo: 4, volume: 106, anno: 1998,
pagine: 449 - 455
SICI:
0903-4641(1998)106:4<449:EOBIFT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN EXPRESSION; EPITHELIAL TUMORS; BREAST-CANCER; ANTIGENS; RECEPTOR;
Keywords:
THYMOMAS; THYMIC CARCINOMAS; BCL-2; P53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P. Engel et al., "EXPRESSION OF BCL-2 IN FETAL THYMUS, THYMOMAS AND THYMIC CARCINOMAS -ASSOCIATION WITH P53 EXPRESSION AND REVIEW OF THE LITERATURE", APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 106(4), 1998, pp. 449-455

Abstract

Bcl-2 is a proto-oncogene inhibiting apoptosis, and p53 is a tumor supressor gene which induces apoptosis. Both seem to take part in tumorigenesis. An inverse relationship between the two genes has been reported in some neoplasms, although the exact mechanism is not fully understood. We have analyzed the expression of bcl-2 and p53 in 18 fetal thymuses and 18 clinically benign and malignant thymomas: bcl-2 was expressed by most medullary lymphocytes and epithelial cells of the normal thymus; p53 was not expressed at all. Bcl-2 and p53 were co-expressed in the majority of the thymomas and the staining reaction was strongerin the clinically malignant ones. It is concluded that although co-expression of bcl-2 and p53 is of doubtful prognostic relevance, the staining pattern of bcl-2 supports the histogenetic classification systemof Muller-Hermelink.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:09:30