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Titolo:
INHALED NITRIC-OXIDE VERSUS CONVENTIONAL THERAPY - EFFECT ON OXYGENATION IN ARDS
Autore:
MICHAEL JR; BARTON RG; SAFFLE JR; MONE M; MARKEWITZ BA; HILLIER K; ELSTAD MR; CAMPBELL EJ; TROYER BE; WHATLEY RE; LIOU TG; SAMUELSON WM; CARVETH HJ; HINSON DM; MORRIS SE; DAVIS BL; DAY RW;
Indirizzi:
UNIV UTAH,DIV RESP CRIT CARE & OCCUPAT PULM MED,SCH MED,DEPT MED,725 WINTROBE BLDG,50 N MED DR SALT LAKE CITY UT 84132 UNIV UTAH,DEPT SURG,SCH MED SALT LAKE CITY UT 84132 UNIV UTAH,DEPT PEDIAT,SCH MED SALT LAKE CITY UT 84132 SALT LAKE CITY ADM MED CTR SALT LAKE CITY UT 00000 UNIV UTAH,UTAH SUPERCOMP CTR SALT LAKE CITY UT 00000
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 5, volume: 157, anno: 1998,
pagine: 1372 - 1380
SICI:
1073-449X(1998)157:5<1372:INVCT->2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; PULMONARY VASCULAR-RESISTANCE; RIGHT-VENTRICULAR FUNCTION; DOSE-RESPONSE; INTRAVENOUS ALMITRINE; IMMUNE-COMPLEXES; SODIUM-TRANSPORT; ORGAN FAILURE; L-ARGININE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Michael et al., "INHALED NITRIC-OXIDE VERSUS CONVENTIONAL THERAPY - EFFECT ON OXYGENATION IN ARDS", American journal of respiratory and critical care medicine, 157(5), 1998, pp. 1372-1380

Abstract

A randomized, controlled clinical trial was performed with patients with acute respiratory distress syndrome (ARDS) to compare the effect of conventional therapy or inhaled nitric oxide (iNO) on oxygenation. Patients were randomized to either conventional therapy or conventionaltherapy plus iNO for 72 h. We tested the following hypotheses: (1) that iNO would improve oxygenation during the 72 h after randomization, as compared with conventional therapy; and (2) that iNO would increasethe likelihood that patients would improve to the extent that the Fi(O2) could be decreased by greater than or equal to 0.15 within 72 h after randomization. There were two major findings. First, That iNO as compared with conventional therapy increased Pa-O2/Fi(O2) at 1 h, 12 h,and possibly 24 h. Beyond 24 h, the two groups had an equivalent improvement in Pa-O2/Fi(O2). Second, that patients treated with iNO therapy were no more likely to improve so that they could be managed with a persistent decrease in Fi(O2) greater than or equal to 0.15 during the72 h following randomization (11 of 20 patients with iNO versus 9 of 20 patients with conventional therapy, p = 0.55). In patients with severe ARDS, our results indicate that iNO does not lead to a sustained improvement in oxygenation as compared with conventional therapy.

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Documento generato il 21/10/20 alle ore 06:17:05