Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE SSN6-TUP1 REPRESSOR COMPLEX OF SACCHAROMYCES-CEREVISIAE IS INVOLVED IN THE OSMOTIC INDUCTION OF HOG-DEPENDENT AND HOG-INDEPENDENT GENES
Autore:
MARQUEZ JA; PASCUALAHUIR A; PROFT M; SERRANO R;
Indirizzi:
UNIV POLITECN VALENCIA,CSIC,INST BIOL MOL & CELULAR PLANTAS,CAMINO DEVERA S-N VALENCIA 46022 SPAIN UNIV POLITECN VALENCIA,CSIC,INST BIOL MOL & CELULAR PLANTAS VALENCIA 46022 SPAIN
Titolo Testata:
EMBO journal
fascicolo: 9, volume: 17, anno: 1998,
pagine: 2543 - 2553
SICI:
0261-4189(1998)17:9<2543:TSRCOS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION PATHWAY; ATF1 TRANSCRIPTION FACTOR; RESPONSE ELEMENT STRE; MAP KINASE CASCADE; PROTEIN-KINASE; SALT TOLERANCE; IMPORTANT DETERMINANT; REGULATORY SEQUENCES; ACTIVATION SITE; FISSION YEAST;
Keywords:
HAL1; HOG PATHWAY; SIGNAL TRANSDUCTION; SSN6; TUP1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Marquez et al., "THE SSN6-TUP1 REPRESSOR COMPLEX OF SACCHAROMYCES-CEREVISIAE IS INVOLVED IN THE OSMOTIC INDUCTION OF HOG-DEPENDENT AND HOG-INDEPENDENT GENES", EMBO journal, 17(9), 1998, pp. 2543-2553

Abstract

The response of yeast to osmotic stress has been proposed to rely on the HOG-MAP kinase signalling pathway and on transcriptional activation mediated by STRE promoter elements. However, the osmotic induction of HAL1, an important determinant of salt tolerance, is HOG independentand occurs through the release of transcriptional repression. We haveidentified an upstream repressing sequence in HAL1 promoter (URSHAL1)located between -231 and -156. This promoter region was able to repress transcription from a heterologous promoter and to bind proteins in nonstressed cells, but not in salt-treated cells. The repression conferred by URSHAL1 is mediated through the Ssn6-Tup1 protein complex and is abolished in the presence of osmotic stress. The Ssn6-Tup1 co-repressor is also involved in the regulation of HOG-dependent genes such asGPD1, CTT1, ALD2, ENA1 and SIP18, and its deletion can suppress the osmotic sensitivity of hog1 mutants. We propose that the Ssn6-Tup1 repressor complex might be a general component in the regulation of osmostress responses at the transcriptional level of both HOG-dependent and -independent genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:56:28