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Titolo:
PREVENTION OF CELL SWELLING WITH LOW CHLORIDE ST-THOMAS-HOSPITAL SOLUTION IMPROVES POSTISCHEMIC MYOCARDIAL RECOVERY
Autore:
JAYAWANT AM; STEPHENSON ER; BAUMGARTEN CM; DAMIANO RJ;
Indirizzi:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,DIV CARDIOTHORAC SURG,PENN STATE GEISINGER HLTH SYST HERSHEY PA 17033 PENN STATE UNIV,MILTON S HERSHEY MED CTR,DIV CARDIOTHORAC SURG,PENN STATE GEISINGER HLTH SYST HERSHEY PA 17033 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHYSIOL RICHMOND VA23298
Titolo Testata:
Journal of thoracic and cardiovascular surgery
fascicolo: 5, volume: 115, anno: 1998,
pagine: 1196 - 1202
SICI:
0022-5223(1998)115:5<1196:POCSWL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC-ARREST; CARDIOPLEGIA; VOLUME; EDEMA; CONSEQUENCES; MYOCYTES; ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Jayawant et al., "PREVENTION OF CELL SWELLING WITH LOW CHLORIDE ST-THOMAS-HOSPITAL SOLUTION IMPROVES POSTISCHEMIC MYOCARDIAL RECOVERY", Journal of thoracic and cardiovascular surgery, 115(5), 1998, pp. 1196-1202

Abstract

Objective: In isolated myocytes cardioplegia-induced cell swelling can be prevented by lowering the KCl product by replacing Cl- with an impermeant ion. This study tested the hypothesis that Cl- substitution in St. Thomas' Hospital cardioplegic solution would result in superior myocardial protection in the intact, blood-perfused heart. Methods: Using a parabiotic, isolated rabbit heart Langendorff model, hearts wereexposed to 1 hour of hypothermic (10 degrees to 12 degrees C), globalischemia followed by 30 minutes of reperfusion. Isosmotic cardioplegia was administered as a single 50 ml bolus of either standard St. Thomas' Hospital solution ([K+](0) x [Cl-](0) = 2566.4 (mmol/L)(2)) or lowCl- St. Thomas' Hospital solution ([K+](0) x [Cl-](0) = 700 (mmol/L)(2)). Chloride was replaced by a large, impermeant ion, methanesulfonate. Postreperfusion systolic function and atrioventricular conduction times were measured before ischemia and after reperfusion, Results: Hearts receiving low Cl- St. Thomas' Hospital cardioplegia demonstrated significantly better postischemic functional recovery (74% +/- 3%) compared with those treated with standard high Cl- St. Thomas' Hospital solution (55% +/- 4%, p = 0.003), In addition, atrioventricular conduction times remained normal in the low Cl- group but were significantly prolonged in the St. Thomas' Hospital group. Conclusions: Lowering the KCI product of St. Thomas' Hospital solution makes it isotonic with plasma and prevents cellular edema. This ameliorates the detrimental functional and electrophysiologic sequelae of hypothermic, hyperkalemic cardioplegia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:52:21