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Titolo:
ENDOTHELIAL-CELL TRANSFECTION WITH CATIONIC LIPOSOMES AND HERPES-SIMPLEX THYMIDINE KINASE MEDIATED KILLING
Autore:
FIFE K; BOWER M; COOPER RG; STEWART L; ETHERIDGE CJ; COOMBES RC; BULUWELA L; MILLER AD;
Indirizzi:
CHARING CROSS & WESTMINSTER MED SCH,DEPT MED ONCOL,ST DUNSTANS RD LONDON W6 8RP ENGLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM LONDON W6 8RP ENGLAND UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT CHEM LONDON ENGLAND
Titolo Testata:
Gene therapy
fascicolo: 5, volume: 5, anno: 1998,
pagine: 614 - 620
SICI:
0969-7128(1998)5:5<614:ETWCLA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-TRANSFER; CYSTIC-FIBROSIS; RETROVIRAL VECTORS; NASAL EPITHELIUM; BRAIN-TUMORS; EXPRESSION; ADENOVIRUS; THERAPY; ANGIOGENESIS; GANCICLOVIR;
Keywords:
ENDOTHELIAL CELL; CATIONIC LIPOSOME; GENE THERAPY; HSV-THYMIDINE KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Fife et al., "ENDOTHELIAL-CELL TRANSFECTION WITH CATIONIC LIPOSOMES AND HERPES-SIMPLEX THYMIDINE KINASE MEDIATED KILLING", Gene therapy, 5(5), 1998, pp. 614-620

Abstract

Endothelial cells are a promising target for cancer gene therapy because neoangiogenesis is vital for the supply of oxygen and nutrients tosolid tumours. However, endothelial cells have been reported to be difficult to transfect. We demonstrate high rates of transfection with the reporter gene pSV40 beta gal using DC-Chol/DOPE cationic liposomes and lower rates with the novel polyamine cationic liposomes ACHx/DC-Chol/DOPE and ACO/CD-Chol/DOPE. Endothelial cells transfected with HSV-thymidine kinase using DC-Chol/DOPE demonstrated 3 log10 increased cytotoxicity compared with controls when exposed to the prodrug ganciclovir, thereby demonstrating significant biological effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:03:10