Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MESOLIMBIC DOPAMINERGIC MECHANISMS UNDERLYING INDIVIDUAL-DIFFERENCES IN SUGAR CONSUMPTION AND AMPHETAMINE HYPERLOCOMOTION IN WISTAR RATS
Autore:
SILLS TL; ONALAJA AO; CRAWLEY JN;
Indirizzi:
CLARKE INST PSYCHIAT,BIOPSYCHOL SECT,250 COLL ST TORONTO ON M5T 1R8 CANADA NIMH,SECT BEHAV NEUROPHARMACOL,EXPT THERAPEUT BRANCH BETHESDA MD 20892
Titolo Testata:
European journal of neuroscience
fascicolo: 5, volume: 10, anno: 1998,
pagine: 1895 - 1902
SICI:
0953-816X(1998)10:5<1895:MDMUII>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; NUCLEUS-ACCUMBENS; EXTRACELLULAR DOPAMINE; INGESTIVE BEHAVIOR; 6-OHDA LESIONS; MICRODIALYSIS; VULNERABILITY; COCAINE; PREDICT; SENSITIZATION;
Keywords:
D-1; D-2; FEEDING; LOCOMOTION; QUINPIROLE; SKF-38393;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Sills et al., "MESOLIMBIC DOPAMINERGIC MECHANISMS UNDERLYING INDIVIDUAL-DIFFERENCES IN SUGAR CONSUMPTION AND AMPHETAMINE HYPERLOCOMOTION IN WISTAR RATS", European journal of neuroscience, 10(5), 1998, pp. 1895-1902

Abstract

Individual differences within strains of rats have been demonstrated for dopamine-mediated behaviours and responses to dopaminergic drugs. Differences in mesolimbic dopamine function may underlie individual differences in some of these behaviours, including sugar consumption andamphetamine hyperlocomotion. The present study addressed two potential mechanisms for these differences in dopamine-mediated behaviours. The possibility of functional differences in dopamine receptor subtypes was tested in LOW and HIGH sugar feeders. LOW and HIGH feeders did notdiffer in their response to the partial D-1 agonist SKF-38393. The highest dose (2.5 mg/kg) of the D-2 agonist quinpirole stimulated locomotor activity to a greater degree in a subset of HIGH sugar feeders as compared with LOW feeders. AII doses of amphetamine induced a greater locomotor response in HIGH feeders as compared with LOW feeders, and HIGH feeders exhibited higher levels of extracellular dopamine in the nucleus accumbens than LOW feeders following exposure to sugar and treatment with amphetamine. These results support the interpretation that LOW and HIGH feeders exhibit differences in presynaptic nucleus accumbens dopamine function that account for the expression of individual differences in sugar consumption and response to amphetamine treatments. A subset of HIGH feeders may also exhibit greater D-2 receptor function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 02:35:07