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Titolo:
THE CEREBRAL-CORTEX - A CASE FOR A COMMON SITE OF ACTION OF ANTIPSYCHOTICS
Autore:
LIDOW MS; WILLIAMS GV; GOLDMANRAKIC PS;
Indirizzi:
UNIV MARYLAND,DEPT ORAL & CRANIOFACIAL BIOL SCI BALTIMORE MD 21201 YALE UNIV,SCH MED,NEUROBIOL SECT NEW HAVEN CT 06510
Titolo Testata:
Trends in pharmacological sciences
fascicolo: 4, volume: 19, anno: 1998,
pagine: 136 - 140
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT PREFRONTAL CORTEX; D2-DOPAMINE RECEPTOR OCCUPANCY; NEURONS IN-VITRO; DOPAMINE-RECEPTOR; SCHIZOPHRENIC-PATIENTS; NEGATIVE SYMPTOMS; ATYPICAL NEUROLEPTICS; COGNITIVE PERFORMANCE; FRONTAL-CORTEX; CLOZAPINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
80
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Lidow et al., "THE CEREBRAL-CORTEX - A CASE FOR A COMMON SITE OF ACTION OF ANTIPSYCHOTICS", Trends in pharmacological sciences, 19(4), 1998, pp. 136-140

Abstract

Recent evidence from studies of receptor occupancy and regulation in post-mortem brains of patients with neuropsychiatric disorders and in non-human primates is providing new leads in the ongoing quest to understand the pathophysiology and causes of schizophrenia and to develop more effective methods of treatment. These studies suggest that the cerebral cortex may harbour the elusive common sites of action of antipsychotic medications and indicate that chronic treatment with these drugs differentially regulates both families of dopamine receptors in this structure. Upregulation of the cortical dopamine D2 receptors is accompanied by a downregulation of the D1 sites. Balancing the opposing actions of dopamine D1 and D2 receptor regulation may hold the key to optimal drug therapy and to understanding the pathophysiology of schizophrenia. In this article, Michael Lidow, Graham Williams and Patricia Goldman-Rakic review the evidence supporting the cerebral cortex as a pivotal site for these mechanisms underlying the action of antipsychotics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:12:35