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Titolo:
OXYGEN-TENSION GRADIENTS AND HETEROGENEITY IN VENOUS MICROCIRCULATION- A PHOSPHORESCENCE QUENCHING STUDY
Autore:
SHONAT RD; JOHNSON PC;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT BIOENGN,9500 GILMAN DR LA JOLLA CA 92093 UNIV ARIZONA,DEPT PHYSIOL TUCSON AZ 85724
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 41, anno: 1997,
pagine: 2233 - 2240
SICI:
0363-6135(1997)41:5<2233:OGAHIV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAMSTER STRIATED-MUSCLE; ARTERIOLAR NETWORKS; CREMASTER MUSCLE; SKELETAL-MUSCLE; TRANSPORT; CAPILLARY; FLOW; EXCHANGE; CELL; MICROVESSELS;
Keywords:
RAT SPINOTRAPEZIUS MUSCLE; PHOSPHORESCENCE LIFETIME; PALLADIUM-PORPHYRIN COMPOUNDS; SPATIAL HETEROGENEITY; LONGITUDINAL OXYGEN GRADIENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Shonat e P.C. Johnson, "OXYGEN-TENSION GRADIENTS AND HETEROGENEITY IN VENOUS MICROCIRCULATION- A PHOSPHORESCENCE QUENCHING STUDY", American journal of physiology. Heart and circulatory physiology, 41(5), 1997, pp. 2233-2240

Abstract

Localized measurements of intravascular oxygen tension (PO2) at multiple locations in the microvascular network of the rat spinotrapezius muscle were used to study the spatial distribution of PO2 in venular structures. By use of a newly developed phosphorescence system to rapidly and repeatedly measure PO2, 538 individual measurements were made in18 different networks during rest. Average intravascular PO2 was (in mmHg +/- SD) 33 +/- 9, 21 +/- 9, 26 +/- 10, and 33 +/- 8 in small arcade arterioles, postcapillary venules (PV), 3 degrees venules (3V), andarcade venules, respectively. The coefficient of variation (CV), a descriptive indicator of spatial heterogeneity, was correspondingly 0.28, 0.45, 0.37, and 0.23 for the different vessel groups. PO2 was found to increase significantly (P < 0.001) from PV to 3V, rising 0.009 +/- 0.002 mmHg/mu m along the vessel. By linear regression, the slope of PO2 for the vessel difference group, PV-SV, as a function of mean systemic blood pressure (BPm; in mmHg) was -0.09 +/- 0.04 (P < 0.05), indicating that the measured longitudinal oxygen gradients and CV are only weakly dependent on BPm. The results support the hypothesis that oxygen can diffuse across the walls of postcapillary vessels and suggest that the venular structures are not merely passive conduits for removingoxygen and waste products but may play an important role in regulating oxygen delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 18:51:47