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Titolo:
CAN CEREBROVASCULAR REACTIVITY BE ASSESSED WITHOUT MEASURING BLOOD-PRESSURE IN PATIENTS WITH CAROTID-ARTERY DISEASE
Autore:
DUMVILLE J; PANERAI RB; LENNARD NS; NAYLOR AR; EVANS DH;
Indirizzi:
LEICESTER ROYAL INFIRM,DEPT PHYS MED LEICESTER LE1 5WW LEICS ENGLAND UNIV LEICESTER,FAC MED,DIV MED PHYS LEICESTER LEICS ENGLAND UNIV LEICESTER,FAC MED,DIV SURG LEICESTER LEICS ENGLAND
Titolo Testata:
Stroke
fascicolo: 5, volume: 29, anno: 1998,
pagine: 968 - 974
SICI:
0039-2499(1998)29:5<968:CCRBAW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE CEREBRAL-ARTERY; CARBON-DIOXIDE REACTIVITY; DOPPLER CO2 TEST; FLOW VELOCITY; OCCLUSIONS; AUTOREGULATION;
Keywords:
BLOOD PRESSURE; CAROTID ARTERY DISEASES; CEREBROVASCULAR REACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J. Dumville et al., "CAN CEREBROVASCULAR REACTIVITY BE ASSESSED WITHOUT MEASURING BLOOD-PRESSURE IN PATIENTS WITH CAROTID-ARTERY DISEASE", Stroke, 29(5), 1998, pp. 968-974

Abstract

Background and Purpose-Conventional methods of assessing cerebrovascular reactivity (CVR) omit the influence of blood pressure (BP). This study demonstrates the significant influence of BP during the assessment of CVR in patients with carotid artery disease. Methods-In 56 subjects the CVR was bilaterally assessed by measurement of cerebral blood flow velocity change in response to inhalation of 5% CO2 in air while BP was continuously monitored. Three methods of calculating the CVR were used: the conventional ratio between relative cerebral blood flow velocity and end-tidal CO2, simple linear regression, and multiple linear regression analysis (MLRA). The clinical significance of the difference in CVR indices was evaluated. The Bland-Altman test was applied toquantify the comparability and bias between measurements. The magnitude and significance of a change in BP during the CVR assessment were calculated in conjunction with an estimate of the velocity change attributed to the BP. The statistical significance of the data segment length on the variability and magnitude of the CVR index was computed. Results-The value of the CVR index was reduced by 20% and 6% in comparison to the conventional ratio approach when MLRA and linear regression were applied, respectively. With the use of MLRA, in 96% of cases the value of the BP coefficient was statistically significant, and in four patients the increase in velocity was primarily attributed to the increase in BP. Conclusions-The influence of BP is significant and requires consideration when the CVR index is calculated in patients with carotid artery disease.

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Documento generato il 01/12/20 alle ore 13:25:18