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Titolo:
ASPIRIN USE AND INCIDENT STROKE IN THE CARDIOVASCULAR HEALTH STUDY
Autore:
KRONMAL RA; HART RG; MANOLIO TA; TALBERT RL; BEAUCHAMP NJ; NEWMAN A;
Indirizzi:
CARDIOVASC HLTH STUDY,1501 4TH AVE,SUITE 2105 SEATTLE WA 98101 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 UNIV TEXAS,DEPT MED,DIV NEUROL SAN ANTONIO TX 78285 UNIV TEXAS,DEPT CLIN PHARMACOL SAN ANTONIO TX 78285 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 JOHNS HOPKINS UNIV,NEURORADIOL DIV BALTIMORE MD 00000 UNIV PITTSBURGH,DEPT GERIATR MED PITTSBURGH PA 00000
Titolo Testata:
Stroke
fascicolo: 5, volume: 29, anno: 1998,
pagine: 887 - 894
SICI:
0039-2499(1998)29:5<887:AUAISI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NITRIC-OXIDE SYNTHASE; HEMORRHAGE; RABBITS;
Keywords:
ASPIRIN; CEREBRAL INFARCTION; CEREBRAL HEMORRHAGE; ELDERLY; RISK FACTORS; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Kronmal et al., "ASPIRIN USE AND INCIDENT STROKE IN THE CARDIOVASCULAR HEALTH STUDY", Stroke, 29(5), 1998, pp. 887-894

Abstract

Background and Purpose-Randomized clinical trials testing aspirin in relatively low-risk, middle-aged people have consistently shown small increases in stroke associated with aspirin use. We analyzed the relationship between the regular use of aspirin and incident ischemic and hemorrhagic stroke among people aged 65 years or older participating inthe Cardiovascular Health Study. Methods-We conducted a multivariate analysis of incident stroke rates in a prospectively assessed, observational cohort of 5011 elderly people followed for a mean of 4.2 years. Results-Participants had a mean age of 72 years, and 58% were women. Twenty-three percent used aspirin frequently, and 17% used aspirin infrequently at study entry. Frequent aspirin use was associated with an increased rate of ischemic stroke compared with nonusers (relative risk=1.6; 95% confidence interval [CI], 1.2 to 2.2; P=0.001). After adjustment for other stroke risk factors, women who used aspirin frequentlyor infrequently at study entry had a 1.8-fold (95% CI, 1.2 to 2.8) and 1.6-fold (95% CI, 0.9 to 3.0) increased risk of ischemic stroke, respectively (P<0.01, test for trend), compared with nonusers. In men, aspirin use was not statistically significantly associated with stroke risk. Findings were similar when aspirin use in the years before the incident stroke was used in the modeling. Aspirin use at entry was also associated with a 4-fold (95% CI, 1.6 to 10.0) increase in risk of hemorrhagic stroke for both infrequent and frequent users of aspirin (P=0.003). Conclusions-Aspirin use was associated with increased risks of ischemic stroke in women and hemorrhagic stroke overall in this elderly cohort, after adjustment for other stroke predictors. The possibility exists of-confounding by reasons for aspirin use rather than cause and effect. Whether regular aspirin use increases stroke risk for elderly people without cardiovascular disease can only be determined by randomized clinical trials.

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Documento generato il 05/12/20 alle ore 01:22:40