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Titolo:
AN IMMUNOHISTOCHEMICAL STUDY OF ENDOTHELIN-1 IN THE HUMAN EYE
Autore:
WOLLENSAK G; SCHAEFER HE; IHLING C;
Indirizzi:
JOHNS HOPKINS UNIV,WILMER EYE INST,EYE PATHOL LAB,MAUMENEE 427,600 N WOLFE ST BALTIMORE MD 21287 UNIV FREIBURG,DEPT PATHOL D-7800 FREIBURG GERMANY
Titolo Testata:
Current eye research
fascicolo: 5, volume: 17, anno: 1998,
pagine: 541 - 545
SICI:
0271-3683(1998)17:5<541:AISOEI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE ENDOTHELIN; VASOCONSTRICTOR PEPTIDE; EPITHELIAL-CELLS; EXPRESSION; RECEPTORS; GANGLIA; RABBIT;
Keywords:
ENDOTHELIN; HUMAN EYE; IMMUNOHISTOCHEMISTRY; PARAFFIN SECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Wollensak et al., "AN IMMUNOHISTOCHEMICAL STUDY OF ENDOTHELIN-1 IN THE HUMAN EYE", Current eye research, 17(5), 1998, pp. 541-545

Abstract

Purpose. Endothelin-1 (ET-1) is a potent vasoconstrictive and neural peptide that has been demonstrated to be present and functionally active and important in the eye. This study was undertaken to examine for the first time the cellular distribution of ET-1 in the whole human eye. Methods. Twelve human eyes were examined by immunohistochemical staining of paraffin sections, using an anti-ET-1 primary antibody and anABC-detection system. Results. Endothelin-1-immunoreactivity (ET-1-IR) was detected primarily in the fibrovascular stroma of the iris, ciliary body and choroid, in the retinal blood vessels, the ciliary and optic nerves, and in the corneal and the non-pigmented ciliary epithelium. Conclusion. In the eye, ET-1-IR is present in fibrovascular, neuraland epithelial structures. Changes in the distribution and concentration of ET-1 may be relevant to a variety of ocular diseases including diabetes mellitus, hypertension, sickle cell disease, optic neuritis, AION, papilledema, corneal ulcer, corneal epithelial dystrophy or after keratoplasty.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:34:33