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Titolo:
INTRAVESICAL ELECTROMOTIVE DRUG ADMINISTRATION TECHNIQUE - PRELIMINARY-RESULTS AND SIDE-EFFECTS
Autore:
RIEDL CR; KNOLL M; PLAS E; PFLUGER H;
Indirizzi:
MUNICIPAL HOSP LAINZ,DEPT UROL VIENNA AUSTRIA MUNICIPAL HOSP LAINZ,LUDWIG BOLTZMANN INST ANDROL VIENNA AUSTRIA
Titolo Testata:
The Journal of urology
fascicolo: 6, volume: 159, anno: 1998,
pagine: 1851 - 1856
SICI:
0022-5347(1998)159:6<1851:IEDAT->2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERFICIAL BLADDER-CARCINOMA; INTERSTITIAL CYSTITIS; MITOMYCIN-C; RECURRENCE; CHLORIDE;
Keywords:
IONTOPHORESIS; ADMINISTRATION, INTRAVESICAL; BLADDER DISEASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Riedl et al., "INTRAVESICAL ELECTROMOTIVE DRUG ADMINISTRATION TECHNIQUE - PRELIMINARY-RESULTS AND SIDE-EFFECTS", The Journal of urology, 159(6), 1998, pp. 1851-1856

Abstract

Purpose: We performed intravesical electromotive drug administration (EMDA) for various bladder disorders during a 3-year period and assessed the technique, possible applications, complications and outcomes ofthis procedure. Materials and Methods: Intravesical EMDA was performed with local anesthetics for transurethral surgery and in combination with dexamethasone for the treatment of noninfectious chronic cystitis(interstitial/radiation cystitis), with mitomycin C for recurrence prophylaxis of high risk superficial bladder cancer and with oxybutynin/bethanechol for the hyperreflexive/ acontractile detrusor. A standardized power source and electrode catheter were used for 215 treatments in 84 patients. Results: Transurethral bladder tumor resections were pain-free in 10 of 12 patients. Of the 25 patients with chronic noninfectious cystitis 15 were free of symptoms for a mean of 6.6 months, and there was a 73% increase in mean bladder capacity from 244 before to 421 cc after EMDA. Of the 16 patients with superficial bladder cancer 9were free of recurrence for a mean of 14.1 months. In 10 of 14 patients with acontractile detrusors urodynamic examination showed detrusor contraction during EMDA of bethanechol. There were no contractions without electric current. EMDA of oxybutynin reduced detrusor hyperreflexia. A bladder ulcer was the single severe local complication and 4.6% of patients, mainly those with chronic cystitis, reported significant post-EMDA bladder/urethral pain. Minor side effects accounted for 23% of all treatments. No systemic side effects occurred. Conclusions: Intravesical EMDA is effective and innocuous. The therapeutic concept combines the advantages of increased drug administration without systemicside effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:05:27