Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEUTROPHIL INHIBITORY FACTOR TREATMENT OF FOCAL CEREBRAL-ISCHEMIA IN THE RAT
Autore:
JIANG N; CHOPP M; CHAHWALA S;
Indirizzi:
HENRY FORD HOSP,DEPT NEUROL,2799 W GRAND BLVD DETROIT MI 48202 HENRY FORD HLTH SCI CTR,DEPT NEUROL DETROIT MI 48202 OAKLAND UNIV,DEPT PHYS ROCHESTER MI 48309 PFIZER LTD,CENT RES SANDWICH CT13 9NJ KENT ENGLAND
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 788, anno: 1998,
pagine: 25 - 34
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; ARTERY OCCLUSION; MONOCLONAL-ANTIBODY; REPERFUSION INJURY; MYOCARDIAL INJURY; CELL-DAMAGE; POLYMORPHONUCLEAR LEUKOCYTES; TISSUE-DAMAGE; TRANSIENT 2H; WISTAR RAT;
Keywords:
HOOKWORM-DERIVED RECOMBINANT NEUTROPHIL INHIBITORY FACTOR (RNIF); CEREBRAL ISCHEMIA; NEUTROPHIL; CD11B/CD18 INTEGRIN; NEURONAL DAMAGE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
N. Jiang et al., "NEUTROPHIL INHIBITORY FACTOR TREATMENT OF FOCAL CEREBRAL-ISCHEMIA IN THE RAT", Brain research, 788(1-2), 1998, pp. 25-34

Abstract

The present study was designed to determine whether a hookworm-derived recombinant neutrophil inhibitory factor (rNIF) is neuroprotective when administered after initiation of focal cerebral ischemia in the rat. We measured the rNIF dose-response on cerebral infarct volume, the therapeutic time window, the therapeutic response to permanent ischemia, and whether rNIF treatment delays the maturation of the ischemic lesion (2 days), or reduces cerebral infarct volume at 7 days after middle cerebral artery occlusion (MCAO). MCAO was induced by an insertion of intraluminal 4-0 monofilament nylon suture into internal carotid artery (n = 195). We demonstrate a significant neuroprotective effect ofrNIF administration 48 h after MCAO in a dose-dependent fashion when treatment was initiated upon reperfusion after 2 h MCAO and maintaineduntil 48 h after MCAO. The beneficial effect was lost under conditions of permanent MCAO. The therapeutic time window is 4 h after MCAO. Brief treatment (6 h) is not sufficient to provide protection for the final ischemic damage. Continuous treatment with a high dose of rNIF fora long duration (7 days) is necessary to achieve maximum neuroprotection. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:25:51