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Titolo:
A TEST OF THE BACKGROUND SELECTION HYPOTHESIS BASED ON NUCLEOTIDE DATA FROM DROSOPHILA-ANANASSAE
Autore:
STEPHAN W; XING L; KIRBY DA; BRAVERMAN JM;
Indirizzi:
UNIV ROCHESTER,DEPT BIOL ROCHESTER NY 14627 UNIV MARYLAND,DEPT ZOOL COLLEGE PK MD 20742 AMERICAN UNIV,DEPT BIOL WASHINGTON DC 20016
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 10, volume: 95, anno: 1998,
pagine: 5649 - 5654
SICI:
0027-8424(1998)95:10<5649:ATOTBS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR GENETIC-VARIATION; X-CHROMOSOME; CENTROMERIC REGION; DNA POLYMORPHISM; STATISTICAL TESTS; MELANOGASTER; POPULATIONS; HITCHHIKING; RECOMBINATION; DIVERGENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
W. Stephan et al., "A TEST OF THE BACKGROUND SELECTION HYPOTHESIS BASED ON NUCLEOTIDE DATA FROM DROSOPHILA-ANANASSAE", Proceedings of the National Academy of Sciences of the United Statesof America, 95(10), 1998, pp. 5649-5654

Abstract

We estimated DNA sequence variation within and between four populations of Drosophila ananassae at Om(ID) and vermilion (v) by using singlestrand conformation polymorphism analysis and direct DNA sequencing, Om(1D) is located on the X chromosome in a region with a normal recombination rate; v is in a region of low recombination. In each population, levels of nucleotide diversity at v are reduced 10- to 25-fold relative to those at Om(ID). Divergence between D. ananassae and its sibling species D. pallidosa, however, is comparable for both loci. This lack of correlation between levels of polymorphism and divergence led tothe rejection of a constant-rate, neutral model. To distinguish amongalternative models, we propose a test of the background selection hypothesis based on the observed pattern of differentiation between populations, Although the degree of differentiation (measured by F-ST) among all I,airs of subpopulations is similar at Om(1D), we found substantial differences at v. The two northern populations from Burma and Nepal are very homogeneous, whereas comparisons between northern and southern populations (e.g., between Nepal and middle India) produced large F-ST values. A coalescent-based simulation of the background selectionmodel (in a geographically structured species with a finite number ofdemes) showed that the observed homogeneity among the northern populations is inconsistent with the background selection hypothesis, Instead, it may have been caused by a recent hitchhiking event that was limited to the northern species range.

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Documento generato il 27/11/20 alle ore 04:44:58