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Titolo:
CHEMICAL LESION OF VISCERAL AFFERENTS CAUSES TRANSIENT OVERCONSUMPTION OF UNFAMILIAR HIGH-FAT DIETS IN RATS
Autore:
CHAVEZ M; KELLY L; YORK DA; BERTHOUD HR;
Indirizzi:
LOUISIANA STATE UNIV,PENNINGTON BIOMED RES CTR,6400 PERKINS RD BATON ROUGE LA 70808 LOUISIANA STATE UNIV,PENNINGTON BIOMED RES CTR BATON ROUGE LA 70808
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 5, volume: 41, anno: 1997,
pagine: 1657 - 1663
SICI:
0363-6119(1997)41:5<1657:CLOVAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VAGAL INNERVATION; CAPSAICIN; CHOLECYSTOKININ; SATIETY; RESPONSES; PATTERNS; NEURONS; SYSTEM; LIVER; TRACT;
Keywords:
CAPSAICIN; FOOD INTAKE; SPINAL AFFERENTS; VAGAL AFFERENTS; GASTROINTESTINAL CONTROL OF FEEDING; MEAL TERMINATION; SATIETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Chavez et al., "CHEMICAL LESION OF VISCERAL AFFERENTS CAUSES TRANSIENT OVERCONSUMPTION OF UNFAMILIAR HIGH-FAT DIETS IN RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 41(5), 1997, pp. 1657-1663

Abstract

Because it is commonly assumed that the major role of visceral afferents in food intake control is to terminate meals by carrying negative-feedback signals to the brain, we hypothesized that overconsumption should occur in rats with chemically lesioned visceral afferents if theywere presented with an unfamiliar diet. Adult male Sprague-Dawley (SD) rats were treated with multiple doses of capsaicin or vehicle as a control. Five weeks later, a series of 3-h feeding tests after 24-h deprivation was carried out, first with chow and then with either a solid(vegetable shortening) or liquid (Ensure) unfamiliar high-fat diet. Both groups consumed similar amounts of their powdered chow maintenancediet, but capsaicin-treated rats consumed at least 50% more of eitherhigh-fat diet than vehicle controls (P <0.01) at the beginning of thefirst trial. During second and third trials with the now-familiar high-fat diet, intake was no longer significantly different between the two groups, suggesting rapid engagement of redundant control mechanisms. These results support a role of capsaicin-sensitive visceral afferents in providing negative feedback for early meal termination during the ingestion of unfamiliar diets.

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Documento generato il 05/12/20 alle ore 23:34:13