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Titolo:
GENDER DIFFERENCE IN THE CYCLE LENGTH-DEPENDENT QT AND POTASSIUM CURRENTS IN RABBITS
Autore:
LIU XK; KATCHMAN A; DRICI MD; EBERT SN; DUCIC I; MORAD M; WOOSLEY RL;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,3900 RESERVOIR RD NW WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20007
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 285, anno: 1998,
pagine: 672 - 679
SICI:
0022-3565(1998)285:2<672:GDITCL>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADES-DE-POINTES; ACTION-POTENTIAL DURATION; III ANTIARRHYTHMIC AGENTS; TRANSIENT OUTWARD CURRENT; RAT VENTRICULAR MYOCYTES; RECTIFIER K+ CURRENT; 2 COMPONENTS; BLOCK; REPOLARIZATION; PROLONGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
X.K. Liu et al., "GENDER DIFFERENCE IN THE CYCLE LENGTH-DEPENDENT QT AND POTASSIUM CURRENTS IN RABBITS", The Journal of pharmacology and experimental therapeutics, 285(2), 1998, pp. 672-679

Abstract

Women are known to have a longer electrocardiographic Q-T than men, which may contribute to their being at greater risk of developing drug-induced polymorphic ventricular arrhythmias. However, little is known about the underlying mechanisms. In the present study, we evaluated potential gender differences in Q-T interval in isolated perfused rabbithearts using the Langendorff technique and evaluated the density of outward potassium currents in single ventricular myocytes using the whole-cell patch-clamp technique. We found that female hearts demonstrated a greater Q-T lengthening (Delta Q-T%) upon an increase in cycle length (CL), resulting in a significantly longer Q-T(301 +/- 4.8 ms, CL =2.3 s) at a long CL in female hearts compared with male hearts (267 +/- 4.0 ms, P < .01). Ventricular myocytes isolated from female hearts showed a smaller I-ktail and peak I-Kl outward current density. A 50% reduction in extracellular K+ and Mg++ shifted the I-V relationship ofI-Kl and I-to and reduced their amplitude. However, neither the I-V relationship of I-Kr nor the gender difference in the Q-T-CL relationship was significantly altered. We conclude that 1) female rabbit ventricular myocytes have significantly lower I-Kr and I-Kl outward current densities than do male cells, which may contribute to the gender difference in Q-T, and 2) a lower base-line I-Kr density may contribute to the steeper Q-T-CL relationship in female hearts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:01:38