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Titolo:
5-HYDROXYTRYPTAMINE(2) RECEPTORS MODULATE AUDITORY FILTERING IN THE RAT
Autore:
JOHNSON RG; STEVENS KE; ROSE GM;
Indirizzi:
LILLY CORP CTR,LILLY RES LABS,DROP CODE 0510 INDIANAPOLIS IN 46285 UNIV COLORADO,HLTH SCI CTR,DEPT PHARMACOL DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT PSYCHIAT DENVER CO 80262
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 285, anno: 1998,
pagine: 643 - 650
SICI:
0022-3565(1998)285:2<643:5RMAFI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; ACOUSTIC STARTLE REFLEX; PREPULSE INHIBITION; SCHIZOPHRENIC-PATIENTS; EVOKED-POTENTIALS; SEROTONIN RELEASE; 5-HT2 RECEPTORS; BRAIN; AMPHETAMINE; ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Johnson et al., "5-HYDROXYTRYPTAMINE(2) RECEPTORS MODULATE AUDITORY FILTERING IN THE RAT", The Journal of pharmacology and experimental therapeutics, 285(2), 1998, pp. 643-650

Abstract

Sensory processing deficits are a hallmark of schizophrenia and can be demonstrated by recording auditory evoked potentials (AEPs) elicitedin response to closely paired click stimuli. In nonschizophrenic humans, as well as in rats, the amplitude of the response to the second click is reduced (filtered) compared with the first. In contrast, schizophrenics, or rats treated with amphetamine, generate AEPs that have smaller amplitudes and show little or no reduction in the response to the second click. We sought to evaluate the role of 5-hydroxytryptamine(2) 5-HT2 receptors in auditory filtering. Male Sprague-Dawley rats were implanted with a skull screw electrode to permit chronic recording of AEPs from a point approximating human vertex. During subsequent recording sessions, pairs of clicks (a conditioning click followed by a test click) were presented 500 msec apart. Parameters of N40, a dominantmidlatency component of the AEP, were examined to evaluate the effects of a 5-HT2 receptor agonist, (+/-)-2,5-dimethoxy-4-iodoamphetamine (DOI), and a 5-HT2 receptor antagonist, ketanserin. Systemic administration of ketanserin reduced sensory filtering in a dose-dependent manner. Conversely, DOI significantly improved filtering. In addition, DOI dose-dependently antagonized the disruption of filtering induced by administration of amphetamine (1.83 mg/kg i.p.). Taken together, these results indicate an important role for 5-HT2 receptors in the modulation of auditory filtering.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:36:24