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Titolo:
DOSE-RESPONSE ANALYSIS OF OPIOID CROSS-TOLERANCE AND WITHDRAWAL SUPPRESSION DURING LAAM MAINTENANCE
Autore:
HOUTSMULLER EJ; WALSH SL; SCHUH KJ; JOHNSON RE; STITZER ML; BIGELOW GE;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BEHAV PHARMACOL RES UNIT,BEHAV BIOL RES CTR BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BEHAV PHARMACOL RES UNIT,BEHAV BIOL RES CTR BALTIMORE MD 21205
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 285, anno: 1998,
pagine: 387 - 396
SICI:
0022-3565(1998)285:2<387:DAOOCA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECIPITATED WITHDRAWAL; PHYSICAL-DEPENDENCE; MORPHINE; HUMANS; BUPRENORPHINE; ABSTINENCE; METHADONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Houtsmuller et al., "DOSE-RESPONSE ANALYSIS OF OPIOID CROSS-TOLERANCE AND WITHDRAWAL SUPPRESSION DURING LAAM MAINTENANCE", The Journal of pharmacology and experimental therapeutics, 285(2), 1998, pp. 387-396

Abstract

Levo-alpha-acetylmethadol (LAAM) currently is approved as an opioid maintenance treatment. This double-blind study was designed to characterize withdrawal suppression and opioid blockade produced by two different LAAM maintenance doses. Outpatient opioid-dependent volunteers were stabilized (5-7 weeks) on 25 (n = 8) or 75 mg (n = 8) LAAM administered every-other-day with placebo administered on intervening days. After stabilization, four inpatient, randomly ordered experimental sessions were conducted at 24, 48, 72 and 96 hr after LAAM dosing; the timing of these sessions corresponds to intervals that occur during typicalthrice-weekly treatment and after a missed dose. During each session,after baseline assessments, ascending doses of hydromorphone (0, 6 and 12 mg i.m.) were administered 45 min apart; physiological, subjective and observer-rated effects were recorded throughout the session. Physiological and subjective indices of opioid withdrawal measured at session base lines increased with time since the last LAAM dose, but did not depend on the maintenance dose, Withdrawal symptoms were mild in both groups, even at 96 hr after LAAM dosing. Hydromorphone produced dose-related opioid agonist effects at all intervals in the 25 mg LAAM group; these effects were attenuated substantially in the 75 mg LAAM group. Time since last LAAM dose had little influence on hydromorphone effects in either group. Thus, 75 mg LAAM provides opioid blockade and withdrawal suppression for up to 96 hr, whereas 25 mg LAAM is relatively ineffective at producing significant opioid blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:49:27