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Titolo:
CORTICOTROPIN-RELEASING FACTOR AND DEFENSIVE WITHDRAWAL - INHIBITION OF MONOAMINE-OXIDASE PREVENTS HABITUATION TO CHRONIC STRESS
Autore:
WARD HE; JOHNSON EA; GOODMAN IJ; BIRKLE DL; COTTRELL DJ; AZZARO AJ;
Indirizzi:
W VIRGINIA UNIV,DEPT PHARMACOL & TOXICOL,ROBERT C BYRD HLTH SCI CTR,POB 9223 MORGANTOWN WV 26506 W VIRGINIA UNIV,DEPT PHARMACOL & TOXICOL,ROBERT C BYRD HLTH SCI CTR MORGANTOWN WV 26506 W VIRGINIA UNIV,DEPT BEHAV MED & PSYCHIAT,ROBERT C BYRD HLTH SCI CTR MORGANTOWN WV 26506 W VIRGINIA UNIV,DEPT PSYCHOL,ROBERT C BYRD HLTH SCI CTR MORGANTOWN WV26506 W VIRGINIA UNIV,DEPT NEUROL,ROBERT C BYRD HLTH SCI CTR MORGANTOWN WV 26506
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 60, anno: 1998,
pagine: 209 - 215
SICI:
0091-3057(1998)60:1<209:CFADW->2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; RAT-BRAIN; FACTOR RECEPTORS; SOCIAL PHOBIA; CLINICAL-PHARMACOLOGY; IMMOBILIZATION STRESS; EXPLORATORY-BEHAVIOR; LOCUS-COERULEUS; DOWN-REGULATION; PANIC DISORDER;
Keywords:
CORTICOTROPIN-RELEASING FACTOR; ANXIETY; DEFENSIVE WITHDRAWAL; PHENELZINE; BEHAVIOR; AMYGDALA; MONOAMINE OXIDASE INHIBITOR; RAT; CHRONIC STRESS; MAO; ANTIDEPRESSANT; CRF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
H.E. Ward et al., "CORTICOTROPIN-RELEASING FACTOR AND DEFENSIVE WITHDRAWAL - INHIBITION OF MONOAMINE-OXIDASE PREVENTS HABITUATION TO CHRONIC STRESS", Pharmacology, biochemistry and behavior, 60(1), 1998, pp. 209-215

Abstract

There is growing evidence for a role of extrahypothalamic corticotropin-releasing factor (CRF) in the pathogenesis of anxiety. A modified form of the defensive withdrawal test was used to test the anxiogenic effects of acute administration of intracerebroventricular (1 mu g, ICV) CRF in adult male rats. Habituation to the mild stress of daily handling and subcutaneous (SC) saline injection over 2-6 weeks abolished the anxiogenic effects of exogenous CRF. At 6 weeks this habituation also resulted in attenuation of baseline withdrawal behavior. CRF receptor binding was significantly decreased in the amygdala of chronically handled animals and may have been responsible for this habituation phenomenon. Comparison of rats treated with the monoamine oxidase (MAO) inhibitor, phenelzine [3 mg/kg, SC, daily for 2-6 weeks] to the saline-treated groups revealed a failure to habituate to the chronic handling, as the baseline withdrawal (after injection of artificial CSF) by the phenelzine-treated animals was not different from the baseline withdrawal by unhandled rats. In comparison to rats treated chronically with saline, phenelzine treatment enhanced the anxiogenic effect of CRF. In summary, habituation to a mild chronic stress decreased baseline defensive withdrawal. Intraventricular administration of CRF produced ananxiogenic response as measured in the defensive withdrawal test, which was lost through exposure to mild chronic stress. Two or 6 weeks ofdaily handling and SC saline injection caused a downregulation of CRFreceptors in the amygdala, which could account for the behavioral habituation and the loss of CRF-induced defensive withdrawal. Phenelzine treatment concurrent with mild chronic stress prevented habituation and maintained the anxiogenic effect of CRF in spite of the downregulation of CRF receptors in the amygdala. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:43:43