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Titolo:
8-OH-DPAT INTERACTS WITH SEXUAL EXPERIENCE AND TESTOSTERONE TO AFFECTEJACULATORY RESPONSE IN RATS
Autore:
ROWLAND DL; HOUTSMULLER EJ;
Indirizzi:
VALPARAISO UNIV,DEPT PSYCHOL VALPARAISO IN 46383 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI BALTIMORE MD 21224
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 60, anno: 1998,
pagine: 143 - 149
SICI:
0091-3057(1998)60:1<143:8IWSEA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIMORPHIC NUCLEUS; RECEPTOR AGONIST; GENITAL REFLEXES; 5-HT1A RECEPTORS; MATING-BEHAVIOR; PREOPTIC AREA; SPINAL-CORD; WISTAR RATS; FEMALE; BRAIN;
Keywords:
8-OH-DPAT; SEXUAL EXPERIENCE; TESTOSTERONE; RAT; 5-HT; SEROTONIN; EJACULATION; COPULATION; SEXUAL BEHAVIOR; INTROMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Rowland e E.J. Houtsmuller, "8-OH-DPAT INTERACTS WITH SEXUAL EXPERIENCE AND TESTOSTERONE TO AFFECTEJACULATORY RESPONSE IN RATS", Pharmacology, biochemistry and behavior, 60(1), 1998, pp. 143-149

Abstract

Studies investigating the effect of 8-OH-DPAT (DPAT) on male sexual response have typically used subjects having variable sexual experienceand levels of testosterone, factors known to independently influence male sexual behavior. This experiment examined the role of these two variables in the mediation of DPAT effects on sexual behavior. One hundred and six castrated males, half of whom received sexual experience, were tested with an effective dose of 8-OH-DPAT (0.1 mg/kg) or saline. In addition, males were tested under one of three regimens of testosterone. Results indicated that DPAT and testosterone exerted independent effects on ejaculatory measures, and along with sexual experience, showed interactive effects as well. When testosterone (T) levels were substantially below normal, DPAT showed no effect. When T reached threshold levels, the DPAT effect was limited to sexually experienced males. At high T levels, both experienced and naive males exhibited strong effects from DPAT. In contrast with ejaculatory measures, mounting andintromitting behaviors were relatively unaffected by DPAT. These results emphasize the importance of specifying both the animal's sexual history and its testosterone profile in studies investigating pharmacological effects on sexual response. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:29:15