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Titolo:
DISCRIMINATION OF ETHANOL IN RATS - EFFECTS OF NICOTINE, DIAZEPAM, CGP-40116, AND 1-(M-CHLOROPHENYL)-BIGUANIDE
Autore:
BIENKOWSKI P; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND WARSAW MED UNIV,DEPT EXPT & CLIN PHARMACOL PL-00527 WARSAW POLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 60, anno: 1998,
pagine: 61 - 69
SICI:
0091-3057(1998)60:1<61:DOEIR->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GATED ION CHANNELS; STIMULUS PROPERTIES; DRUG DISCRIMINATION; INTEROCEPTIVE CUE; NMDA ANTAGONISTS; 5-HT3 RECEPTORS; MODULATION; SUBSTITUTION; ALCOHOL; POTENTIATION;
Keywords:
ETHANOL; NICOTINE; LIGAND-GATED ION CHANNELS; DRUG COMBINATIONS; DRUG DISCRIMINATION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
P. Bienkowski e W. Kostowski, "DISCRIMINATION OF ETHANOL IN RATS - EFFECTS OF NICOTINE, DIAZEPAM, CGP-40116, AND 1-(M-CHLOROPHENYL)-BIGUANIDE", Pharmacology, biochemistry and behavior, 60(1), 1998, pp. 61-69

Abstract

The drug discrimination paradigm was used to evaluate the role of certain ligand-gated ion channels in the discriminative stimulus properties of ethanol. Rats were trained to discriminate ethanol (1.0 g/kg) from saline vehicle under the FR10 schedule of sweetened milk reinforcement. The discrimination of lower ethanol doses was enhanced by either the GABA(A) receptor positive modulator, diazepam (0.5 mg/kg), or nicotinic acetylcholine receptor agonist, nicotine (0.3 mg/kg). Neither diazepam nor nicotine produced any effect on the rate of responding. Both the NMDA receptor competitive antagonist, CGP 40116 (0.5 mg/kg) and the 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide (5.0 mg/kg) enhanced the cueing properties of lower ethanol doses, but these effects were associated with a significant reduction in the response rate. The ethanol-like stimulus effects produced by diazepam or CGP 40116 were not influenced by 0.3 mg/kg nicotine. In contrast; CGP 40116 moderately enhanced the ethanol-like stimulus effects of diazepam. The present results show that: 1) pretreatment with nicotine, diazepam, CGP 40116 or 1-(m-chlorophenyl)-biguanide enhance the ethanol discrimination; 2) neither the GABA(A) nor the NMDA receptor complex alone is critically involved in the nicotine-induced enhancement of the ethanol discrimination; 3) NMDA receptor competitive antagonist and GABAergic benzodiazepine derivative may produce moderate additive effects in rats trained to discriminate ethanol. (C) 1998 Elsevier Science Inc.

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Documento generato il 15/07/20 alle ore 08:13:52