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Titolo:
NITRIC-OXIDE SYNTHASE INHIBITORS ALTER VENTILATION IN ISOFLURANE-ANESTHETIZED RATS
Autore:
PATEL GM; HORSTMAN DJ; ADAMS JM; RICH GF;
Indirizzi:
UNIV VIRGINIA,DEPT ANESTHESIOL,POB 10010 CHARLOTTESVILLE VA 22906 UNIV VIRGINIA,DEPT ANESTHESIOL CHARLOTTESVILLE VA 22906 UNIV VIRGINIA,DEPT BIOMED ENGN CHARLOTTESVILLE VA 22906
Titolo Testata:
Anesthesiology
fascicolo: 5, volume: 88, anno: 1998,
pagine: 1240 - 1248
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXHIBITS ANTINOCICEPTIVE ACTIVITY; ARGININE METHYL-ESTER; BRAIN BLOOD-FLOW; 7-NITRO INDAZOLE; GRADED REDUCTION; ANESTHESIA; THRESHOLD; DEPRESSION; HALOTHANE; RECEPTOR;
Keywords:
ANESTHESIA; HYPERCAPNIA, MINUTE VENTILATION; N-G-L-ARGININE METHYLESTER; 7-NITRO-INDAZOLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Patel et al., "NITRIC-OXIDE SYNTHASE INHIBITORS ALTER VENTILATION IN ISOFLURANE-ANESTHETIZED RATS", Anesthesiology, 88(5), 1998, pp. 1240-1248

Abstract

Background: Nitric oxide (NO) is present in medullary structures and can modulate respiratory rhythm. The authors determined if spontaneousventilation at rest and in response to increased carbon dioxide is altered by selective neuronal NO synthase (NOS; 7-nitro-indazole, 7-NI) or nonselective (neuronal plus endothelial) NOS (N-G-L-arginine methylester [L-NAME] and N-G-monomethyl L-arginine [L-NMMA]) inhibitors in rats anesthetized with isoflurane. Methods: Fifty-four rats received either L-NAME or L-NMMA (1, 10, and 30 mg/kg) or 7-NI (20, 80, and 400 mg/kg) and were compared with time controls (isoflurane = 1.4%), with isoflurane concentrations (1.6%, 1.8%, and 2%) increased consistent with the increased anesthetic depth caused by NOS inhibitors, or with L-arginine (300 mg/kg). Tidal volume (V-T), respiratory frequency (f), minute ventilation ((V)over dot(E)), and ventilatory responses to increasing carbon dioxide were determined. Results: L-NAME and L-NMMA decreased resting V-T and (V)over dot(E), whereas 7-NI had no effect. Increasing concentrations of isoflurane decreased resting f, V-T, and (V)over dot(E). L-NAME and L-NMMA decreased V-T and (V)over dot(E), whereas7-NI had no effect at 8%, 9%, and 10% end-tidal carbon dioxide (ETCO2). Increasing concentrations of isoflurane decreased f, V-T, and (V)over dot(E) at 8%, 9%, and 10% ETCO2. The slope of (V)over dot(E) versusETCO2 was decreased by isoflurane but was unaffected by L-NAME, L-NMMA, or 7-NI. L-arginine alone had no effect on ventilation. Conclusions: Nonselective NOS inhibitors decreased V-T and (V)over dot(E) at restand at increased carbon dioxide levels but did not alter the slope ofthe carbon dioxide response. Selective neuronal NOS inhibition had noeffect, suggesting that endothelial NOS may be the isoform responsible for altering ventilation. finally, the cause of the decreased ventilation is not a result of the enhanced anesthetic depth caused by NOS inhibitors.

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Documento generato il 12/07/20 alle ore 09:10:42