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Titolo:
STUDIES ON THE ROLE OF NICOTINIC ACETYLCHOLINE-RECEPTORS IN THE DISCRIMINATIVE AND AVERSIVE STIMULUS PROPERTIES OF ETHANOL IN THE RAT
Autore:
BIENKOWSKI P; PIASECKI J; KOROS E; STEFANSKI R; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND MED HIGH SCH,DEPT EXPT & CLIN PHARMACOL PL-00527 WARSAW POLAND
Titolo Testata:
European neuropsychopharmacology
fascicolo: 2, volume: 8, anno: 1998,
pagine: 79 - 87
SICI:
0924-977X(1998)8:2<79:SOTRON>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED TASTE-AVERSION; SHORT-SLEEP MICE; GATED ION CHANNELS; LONG-SLEEP; ALCOHOL; SUBSTITUTION; SENSITIVITY; MORPHINE; DRUGS; NMDA;
Keywords:
ETHANOL; NICOTINE; NICOTINIC ACETYLCHOLINE RECEPTOR; DRUG DISCRIMINATION; CONDITIONED TASTE AVERSION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
P. Bienkowski et al., "STUDIES ON THE ROLE OF NICOTINIC ACETYLCHOLINE-RECEPTORS IN THE DISCRIMINATIVE AND AVERSIVE STIMULUS PROPERTIES OF ETHANOL IN THE RAT", European neuropsychopharmacology, 8(2), 1998, pp. 79-87

Abstract

The role of the nicotinic acetylcholine receptor (nAChR) in the discriminative and aversive stimulus effects of ethanol was studied in rats. In the operant drug discrimination procedure the rats were trained to discriminate between 1.0 g/kg ethanol and saline under the FR10 schedule of sweetened milk reinforcement. Neither the nAChR agonist, nicotine (0.1-0.6 mg/kg) nor the nAChR antagonist, mecamylamine (3.0-6.0 mg/kg) substituted for the ethanol stimulus. Moreover, mecamylamine (0.5-6.0 mg/kg) did not antagonise the ethanol stimulus. The cross-familiarisation conditioned taste aversion procedure was used as an alternative method to study stimulus resemblance between ethanol and nicotine. Six daily injections of nicotine (0.6 mg/kg) significantly decreased asubsequent ethanol-induced taste aversion conditioning. The aversive stimulus effects of ethanol were investigated with the conditioned taste aversion (CTA) paradigm. Mecamylamine (1.0-3.0 mg/kg) did not attenuate an ethanol-induced CTA. These results suggest that: (1) nAChRs are not primarily involved in the discriminative stimulus effects of ethanol when studied with the operant drug discrimination test; (2) nAChRs are not critically involved in the ethanol-induced CTA. (C) 1998 Elsevier Science B.V./ECNP.

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Documento generato il 29/03/20 alle ore 18:08:54